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Tag: cells

UK’s first canine clone is born in Seoul

miniwinnie

With more than 500 canine clones now roaming the world, you wouldn’t think the fact that one has been produced for a pet owner in the UK would make such a big splash.

But it has, and a big splash is just what the cloners had in mind.

To introduce its unique service to Britain, Sooam Biotech, the South Korean laboratory that’s now the only company cloning dogs, borrowed from an earlier chapter in dog cloning’s bizarre history. It held a public contest, awarding a free cloning as the grand prize.

The winner: Rebecca Smith, 29, of London, who learned in late March that a clone of her 12-year-old dachshund Winnie had been born in a Seoul laboratory, BBC reported.

She named the dog Mini Winnie.

The competition saw dog owners submit videos of their dogs and compete for the chance to “immortalize” their pet for free. The bill for dog cloning normally runs around $100,000.

“Sooam Biotech is looking for one person with the most special and inspiring reason for cloning his/her beloved dog,” the company said in announcing the contest.

The contest was similar to one held in the U.S. when dog cloning first hit the market. It was called the “Golden Clone Giveaway,” and the winner was TrakR, a search and rescue dog whose owner said the German shepherd found the last survivor in the rubble of 9/11.

The weird and wacky story of how dog cloning was achieved, how it was marketed, and the first customers to sign up for it can be found in my book, “DOG, INC.: The Uncanny Inside Story of Cloning Man’s Best Friend.”

The UK’s first canine clone — who won’t arrive in the country until after a 6-month quarantine period — was cloned at Sooam Biotech, a laboratory run by Hwang Woo Suk, who was a member of the Seoul National University team that produced the world’s first canine clone, Snuppy, in 2005.

That research began after an earlier effort to clone a dog in the U.S., at Texas A&M University, was unsuccessful.

The Texas A&M research was funded by John Sperling, founder of the University of Phoenix. After cloning a cat, and assorted farm animals, the Texas A&M efforts to clone a dog were called off, but Sperling’s front man, who had established a company to store the cells of dead and dying dogs (Genetic Savings & Clone), even before dog cloning was achieved, later teamed up Hwang and Sooam to offer an online auction, with the highest bidders receiving clones of their dogs.

SONY DSCHwang founded his lab after getting fired from Seoul National University when his claim to have produced the world’s first cloned human embryos was deemed fraudulent. He was later convicted of embezzling research funds and illegally buying human eggs, but his 18-month sentence was suspended.

Hwang has more recently has embarked on trying to clone a woolly mammoth from 10,00-year-old remains found frozen in Siberia.

Meanwhile, he’s churning out laboratory-created dogs, more than 500 of which have been born to surrogate mother dogs at his lab and kennel.

To create Mini Winnie, a piece of skin was taken from Winnie and transported to Seoul. Cells from the sample were placed inside an anonymous donor dog’s egg cell and, with a jolt of electricity, they merged.

Then the embryo was implanted inside a surrogate dog that gave birth, via Caesarean, to Winnie on March 30.

“The world would be a better place with more Winnies in it,” Smith, 29, says in a Channel 4 documentary, “The £60,000 Puppy: Cloning Man’s Best Friend.”

smithandwinnieSmith received the original Winnie as a present on her 18th birthday, and she says the dog helped her overcome “lots of demons,” including an eating disorder. Smith says Mini Winnie looks identical to the original, who is old and arthritic, but still alive.

Hundreds of pet owners have had dogs cloned since the first customer, a California woman who received five copies of her dead pit bull, Booger.

Critics of the process say cloning doesn’t result in the resurrection of an animal, but a laboratory-made twin, whose creation requires the involvement of numerous other dogs, and who might not act like the original at all.

Initially, two South Korean companies were cloning dogs for pet owners (and even more for research purposes), but one of the, RNL Bio, has pulled out of the dog-cloning business.

While the cloning process has grown more efficient, some animal welfare groups say risks are still high.

Dr Katy Taylor, Head of Science at The British Union for the Abolition of Vivisection, said: “Cloning is a very unpredictable and extremely wasteful process … In order to produce just one ‘perfect’ clone, many puppies with the same genes as a loved animal will be born … Some of these puppies will be aborted or will die soon after birth from unpredictable health complications and severe birth defects.”

Defective pups, and the South Korean laboratory’s failure to follow animal welfare protocols, were among the reasons cited by the American company that teamed up with Hwang for pulling out of its dog cloning arrangement.

The documentary, while it mostly follows the judges as they visit with contestants and their dogs, does go some interesting places, including Edinburg, for an interview with Sir Ian Wilmut, cloner of Dolly the sheep. Wilmut doesn’t endorse pet cloning, and says he remains skeptical of it, saying it will lead to lots of disappointed customers who, despite their hopes, won’t get an animal with the same personality as the original.

There’s also an interview with a pet owner, not a contestant, who views dog cloning as a Hitleresque pursuit, and there are several allusions to the fact that some Koreans eat dog meat.

“The £60,000 Puppy: Cloning Man’s Best Friend” was made by the same independent production company that produced “I Cloned My Pet,” several episodes of which appeared on TLC.

“The £60,000 Puppy” is an improvement over those productions, which brushed aside most ethical questions and animal welfare concerns about pet cloning. While the new documentary doesn’t delve too deeply into them either, it does present something more than a one-sided view.

Like the earlier documentaries, it reinforces that most customers of dog cloning are, shall we say, eccentric sorts, and that their attachment to their dogs — as with all of us — is a powerful one.

Perhaps the most telling moment, though, comes as the judges debate — American Idol style — the public relations benefits of each contestant.

After that, the winner is … after a long, long pause … announced.

Cloning, it seems, is no longer some futuristic pipedream. It has become a reality, and apparently an entertainment form.

My view? Cloning is no game show, or at least it shouldn’t be.

(Photos: Top, Mini Winnie / Channel 4; middle, Hwang in his lab / John Woestendiek; bottom; Smith and the original Winnie / Channel 4)

Will stem cells bring Bentley’s legs back?

Bentley, a 2-year-old Great Pyrenees with a torn ligament and an arthritic joint in his back leg, was reinjected with his own stem cells this week — a process veterinarians hope will have him running, or at least walking comfortably again, in a matter of weeks.

The procedure – performed on the 105-pound dog at the American Animal Hospital in Randolph, New Jersey — was described as the first one-day, animal stem cell transplant procedure in New Jersey history.

Vets hope the treatment will stimulate cell regeneration in Bentley, reduce inflammation and ease his pain.

“I just want to give Bentley some relief, just so I can walk him again. I’m not expecting him to be a marathon runner,” owner Erin McGuire, who drove her dog 80 miles from Brielle for the treatment, told the Newark Star-Ledger.

The procedure was overseen by Michael Hutchinson, a veterinarian from the Pittsburgh area who has performed similar ones on about 100 dogs, cats and even horses since 2008.

Although the procedure is approved only for animal ailments such as hip dysplasia, arthritis and ligament injuries, it is being looked at — and used in some other countries — to solve human health problems as well.

“The basic procedure involves taking fat from the dog, extracting stem cells and injecting those stem cells back into the dog,” said Brian T. Voynick, owner and director of the Randolph veterinary hospital.

Voynick was the first veterinarian in New Jersey to use stem cell treatment with animals three years ago — a prolonged, multi-day procedure at the time.

After he removed 60 grams of fat from the dog, he’d have to send it to California to be processed, and wait for the stem cells to be shipped back. Bentley’s treatment, in which the stem cells were separated from the fat on site, took less than four hours at Voynick’s hospital Wednesday.

Voynick and Hutchinson removed 16 grams of fat from under the dog’s left shoulder, mixed it with platelets extracted from the dog’s blood and enzymes, incubated the serum, spun it in a centrifuge and finally exposed it to wavelengths of LED lighting under a process patented by an Australian-based company called MediVet.

Bentley was given a good prognosis Wednesday, but only time will tell if the procedure was successful, the Star-Ledger reported.

The inner workings of a cold slimy nose

Many a dog owner has wondered what’s going on in their pooch’s head — but even more fascinating may be what’s going on in his nose.

A team of Pennsylvania State University researchers, led by Brent Craven, say that the layer of mucus in a dog’s nose helps it pick up and sort scents as they travel to receptors.

Or, as New Scientist magazine put it, “Dogs extraordinary ability to sniff out anything from cocaine to cancer turns out to owe much to the gunk inside their nose.”

Dogs have many more nerve cells in their nasal cavities — and a complex network of snot-coated tubes that also “pre-sorts” smells, which may make it easier for the brain to identify them.

Craven and his colleagues used MRI images of a dog’s nasal airways to develop computer models of how air travels thorugh them. The researchers observed that different molecules were picked up by nerve cells at different points along the nasal passages.