Scientists studying compulsive behaviors in Doberman pinschers have located a gene they believe is associated with OCD — a finding that could lead to pinpointing a genetic source of obsessive-compulsive disorder in humans.
In dogs, compulsive behavior includes tail chasing, licking their legs until they develop infections, and pacing and circling — canine versions, perhaps, of repeated hand washing and other behaviors displayed by the 2.2 million Americans estimated to be affected by the disorder.
The Doberman study was done by researchers at the Cummings School of Veterinary Medicine at Tufts University, the University of Massachusetts Medical School in Worcester, and the Broad Institute, according to the Boston Globe.
Scientists took samples from 92 Doberman pinschers that displayed compulsive behavior. Dogs with the disorder compulsively suck their flanks or blankets. Researchers also used samples from 68 normal dogs, and did a genome-wide scan, searching for spots that varied between the two samples.
They found a genetic hot spot in dogs with the compulsive behavior — within in a gene called Cadherin 2, known to be active in the brain and in a family of genes recently implicated in autism.
Dr. Dennis Murphy, a laboratory chief in the National Institute of Mental Health, said he is working to follow the research by studying the same gene in more than 300 human patients with OCD, 400 of their relatives, and about 600 people without OCD.
“Identifying a specific gene that could be a candidate gene for a complex disorder like OCD is a gift to have,’’ Murphy said. “This might be a quick route in to a meaningful gene that just could be involved in the human disorder, as well.’’
Posted by jwoestendiek January 5th, 2010 under Muttsblog.
Tags: animals, broad institute, circling, compulsive, dennis murphy, disorder, doberman pinschers, dobermans, dogs, gene, genes, genome, licking, mental health, national institute of mental health, obsessive, ocd, pacing, pets, research, science, study, tail chasing, tufts university, university of massachusetts