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Tag: cloning

Dogs like running, therapy dogs make people feel good, and other “oh duh” studies

In my daily perusal of what in the world is going on with dogs, I am constantly amazed at how many studies are done on things we already know — and how quick news organizations are to pounce on those studies and present them as something new.

Take last week’s Washington Post, which tells us in a headline, “Dogs can get a runner’s high, too.”

Pfffft. Dogs invented the runner’s high. We didn’t need a headline to know, least of all one based on a 2012 study.

The article goes on to tell us that running is healthy for dogs and humans, that running “gives dogs an activity and burns energy,” and, of course, that dogs and humans should check with their vets and doctors before beginning an exercise program.

I don’t know how much of this stating of the painfully obvious that goes on today is because we have run out of new things to say, study and report on; or how much is the result of so-called news websites providing dumbed-down “content,” instead of news.

But it seems like everybody — from scientist to journalist — is in repeat mode. Or maybe I’m just old.

SONY DSCAlso making news last week was the “recent finding” that dogs respond best to high-pitched voices.

This, at least, stems from a new study in which scientists at the University of York have shown that using high-pitched baby-talk voices can help us bond with their dogs.

Of course, the study found basically the same thing as others in recent years, including this one from more than a year ago.

Now any scientist will tell you that’s there is value in these studies that tell us what we already know — whether we already know them from common sense, or because of similar earlier studies that found the same thing. It is always good to confirm things

News organizations, on the other hand, will take the findings of any study, hype them up and present them as the most important breaking news of the day — even if they did the same thing last year, and the year before that, and the year before that.

They know, even with Google, our collective memory is short, so they trot out the same old pieces regularly — should you let your dog sleep with you, should you let your dog lick you, why do dogs eat grass? — and they either find experts or studies to legitimize them.

Just last week, with the news that Barbra Streisand has two cloned dogs, the topic of dog cloning became instantly hot, and many a news outlet presented the story in a you’re-not-going-to-believe-this, dogs-are-being-CLONED!!! kind of way.

Having written a book on the very topic seven years ago, I was amused how the news was suddenly a revelation again.

I’m sure scientists somewhere are studying how short our memories and attention spans are becoming, and that I’ll be reading about it soon.

Until then, there will be plenty of other scientific “revelations” to keep me busy, like this one — unearthed by hardworking researchers at the University of British Columbia:

Therapy dogs make people feel good.

acetWell, that’s kind of why they have been popping up everywhere in the past 20 years — to do just that.

And what led to those initial revelations, years ago? Studies.

This new one, published in the journal Stress and Health, shows that exposure to therapy dogs helps boost students’ well-being. Researchers interviewed 246 students before and after cuddle and petting sessions with therapy dogs.

Students felt significantly less stressed and more energized after interacting with the dogs, though the happy feelings weren’t necessarily lasting, InsideHigherEd.com reported.

In other words, the feel-good vibe a dog gives you — like a news report, like a scientific study, like many a book — will soon be forgotten.

(Photos by John Woestendiek / ohmidog!)

Barbara Streisand has cloned her dog twice

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Having literally written the book on the first customers of dog cloning, and having tried to keep you posted since then on developments in that morbid and exploitative business, I must report here on one of its newest customers.

Barbra Streisand.

In a far-ranging interview with Variety, the singer and show business legend revealed that her dogs Miss Violet and Miss Scarlett are both clones of her original Coton du Tulear, Samantha.

Samantha, who commonly accompanied Streisand to concerts and public appearances, and who had her own Instagram fans, died last fall at the age of 14.

In the Variety article, Streisand offered few specifics on how she made the decision to clone, or on the process itself, but either Samantha’s corpse, or cell samples from it, were sent to South Korea where they were cloned in a private lab operated by a once-disgraced scientist — the same one who was involved in the world’s first canine cloning.

Her two new pups were cloned at Sooam Biotech, using cells extracted from Samantha’s mouth and stomach.

In the process, the donor cells are merged with egg cells extracted from other dogs, zapped with an electrical current to spur splitting, then implanted in more dogs who serve as surrogates, carrying the embryos to pregnancy.

Often surplus clones result — those that don’t have the exact same markings. Through cloning’s development, death and deformities resulted as well. Animal welfare groups frown on the practice, because of the intrusive procedures the other dogs go through, and because it is generally quite easy to simply adopt a dog that looks like the one you just lost.

Streisand, from what I’ve read about her, seems to fit the common mold of dog cloning’s earliest customers — wealthy eccentrics unwilling to accept nature taking something away from them, who feel they have every right to get it back, no matter how much pain and suffering other dogs might go through for that to be achieved.

They weren’t all wealthy — including the very first customer — but they all were controlling sorts who often didn’t even recognize the utter selfishness of what they were doing.

They were also, early on, misled by the dog cloning companies that formed after the successful cloning of Snuppy in South Korea in 2005. Not only would the clone be an exact physical replica, but it would have the same endearing traits and personality of the original, they were told by the emerging dog cloning companies.

That part was bunk, and the companies later toned down their claims. As the process became more efficient, they dropped their prices too, from $150,000, to under $100,000, with some companies now offering a price as low as $25,000.

In the Variety article, Streisand’s two clones were mentioned as an aside, much like her husband, actor James Brolin, often is.

Along with her husband of 20 years, James Brolin, there’s no one she enjoys sharing her residence with more than her three Coton de Tulear dogs. Perhaps her biggest reveal: Miss Violet and Miss Scarlett were cloned from cells taken from the mouth and stomach of her beloved 14-year-old dog Samantha, who died in 2017. Miss Fanny is a distant cousin.

“They have different personalities,” Streisand says. “I’m waiting for them to get older so I can see if they have her brown eyes and her seriousness.”

Streisand, the article said, even suggested a cutline for the magazine to use with the photo they took of her and her dogs — Send in the Clones.

Streisand said that when the clones first arrived, she dressed one in red and one in lavender, so she could tell them apart. That’s what led to their names — Miss Scarlett and Miss Violet.

I don’t suspect Streisand looks at her new clones and sees in them the reincarnated soul of her original dog, as some early customers did.

I do suspect that original dog created memories she wanted to hold on to, at any cost.

Like the song she once sang, “The Way We Were,” asked:

Can it be that it was all so simple then?
Or has time re-written every line?
If we had the chance to do it all again
Tell me, would we? Could we?

The answer is — if you have more money than you know what to do with, if you have little regard for animals other than your own, if you have a selfish streak and an ability to delude yourself — yes!

(Photo: Streisand holding Miss Violet and Miss Scarlett, along with Miss Fanny (from left), who is distantly related and given to Streisand while was waiting for the clones; by Russell James / Variety)

Chinese scientists clone the world’s first primate; two macaque monkeys are born

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Nearly 13 years after the cloning of a dog, the species man is emotionally closest to, Chinese scientists have announced the first successful cloning of the animal man is physically closest to — the monkey.

Using the same basic technique that created Dolly the sheep in Scotland, the world’s first cloned mammal, and Snuppy the Afghan hound in South Korea, scientists in China produced two identical clones of a macaque, reigniting concerns among some that attempts to clone man are on the horizon.

The newborns — the world’s first cloned primates — were named Zhong Zhong and Hua Hua, after a Mandarin term for the Chinese nation and people.

The two healthy baby macaques were the only ones to survive to birth out of 127 altered egg cells implanted into more than 60 surrogate mothers.

The scientists behind the project said they followed the techniques of somatic cell nuclear transfer, but made a few refinements along the way. Unlike with Dolly and Snuppy, fetal cells were used rather than adult ones

Mu-ming Poo, director of the Chinese Academy of Sciences’s Institute of Neuroscience in Shanghai, who led the work, said further refinement of their methods would lead to higher success rates, Combining the cloning with gene editing will allow researchers to create “ideal nonhuman primate models” for studying disease mechanisms and screening drugs, he said.

So in answer to the seldom asked (at least by scientists) question — why clone monkeys? — that’s your immediate answer: As fodder for laboratory experiments.

The team behind the monkey cloning acknowledges that the work raises ethical questions, but Poo said he doubted it would lead to cloning man: “I would think society and the general public and governments will not allow extension of this method from nonhuman primates to humans.”

Science magazine reports that ethicists are also concerned about the monkeys themselves. “At present, it has not been sufficiently demonstrated that there are no alternatives to using macaque monkeys for such research,” Peter Dabrock, an ethicist at Friedrich-Alexander University in Erlangen, Germany, wrote in a statement.

Using nonhuman primates for research is more accepted in China than in the West, Poo said, adding “Once we demonstrate the cloned monkey’s usefulness in curing disease, I hope [Western societies] will gradually change their minds.”

He said the group is following international guidelines for the treatment and care of their monkeys.

Scientists around the world have cloned more than 20 species since Dolly the sheep was created in 1996, including dog, cat, horses, pigs, cows, rabbits, rats and mice,

Attempts to clone primates, however, had been unsuccessful, and some experts suspected primates might be resistant to the procedure.

The Chinese team reported in the Feb. 8 edition of the journal Cell that it’s difficult, but possible. The team succeeded, after many attempts, by using modulators to switch on or off certain genes that were inhibiting embryo development.

In all, it took more than 100 egg cells — merged with donor cells and implanted into surrogates — to produce two live macaque births.

Using adult cells, they achieved 22 pregnancies in 42 surrogates. That produced two births but neither survived. When they cloned using fetal monkey cells, six pregnancies were confirmed in 21 surrogates and yielded two healthy babies.

While the scientists celebrate their achievement, animal welfare groups, including PETA, condemned it.

“Cloning is a horror show: A waste of lives, time, and money – and the suffering that such experiments cause is unimaginable,” said Dr. Julia Baines, Science Policy Adviser at PETA UK. “Because cloning has a failure rate of at least 90 per cent, these two monkeys represent misery and death on an enormous scale.”

(Photo: Qiang Sun and Mu-ming Poo/Chinese Academy of Sciences)

Chinese scientists clone dogs with heart disease — and call it an achievement

longlong

China says it has managed to join South Korea as a world leader in canine cloning — by managing to create a clone of a sick dog.

Longlong, a beagle, was born with a blood-clotting disorder, and that was just what the scientists were hoping for.

The pup is a clone of Apple, a different dog whose genome was edited to develop the disease atherosclerosis, CNN reported.

longlong1By cloning the bioengineered dog, the scientists ensured they will have a good supply of diseased dogs for experiments they say could lead to cures for the condition that causes strokes and heart disease in humans.

Longlong was created by the Beijing-based biotech company Sinogene, which is boasting about having created the world’s first dog cloned from a gene-edited donor.

With Longlong’s birth, and two more clones of the bio-engineered dog being born since then, the scientists claimed that China had matched South Korea as a leader in canine cloning technology. South Korean scientists cloned the first dog, an Afghan hound named Snuppy, in 2005.

“Dogs share the most inheritable diseases with human beings, which makes them the best disease models to study,” says Feng Chong, technical director at Sinogene.

While the pups haven’t shown any signs of cardiovascular disease yet, their cloning ensures they will get it. Experimental drugs to treat cardiovascular diseases are already being tested on them.

Longlong’s birth combined two technologies: A gene-editing tool called CRISPR with somatic cell cloning technology, the method used to clone Dolly the sheep and later, Snuppy.

Zhao Jianping, vice manager of Sinogene, says the company’s success in dog cloning is about 50%. Two surrogate dogs out of four gave birth to three cloned puppies. The other two did not get pregnant.

Scientists at Sinogene believe their work aids the future of pharmaceutical development and biomedical research and it plans to produce more cloned dogs like Longlong.

“Gene-edited dogs are very useful for pharmaceutical companies,” said Feng. “The supply falls short of the demand every year.”

(Poor little pharmaceutical companies.)

The scientists also say cloning bio-engineered dogs to create puppy clones that will be born with the disease is kinder than the previous method of creating atherosclerosis in lab dogs — namely, force feeding with meals high in sugar.

Scientists, in case you haven’t noticed, have also invented a way to justify just about anything they want to do.

So if you want to hail this as a great achievement in technology, go ahead. I prefer to see it as scientists taking another giant stride toward playing God — giveth-ing life to dogs, only to taketh it away. Mankind may benefit (or at least live a longlong time), but rest assured the biggest gains will go to pharmaceutical companies.

(Photos: CNN)

South Korean university announces that Snuppy has been recloned

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The world’s first canine clone — an Afghan hound named Snuppy who died in 2015 — has been recloned, scientists at Seoul National University in Korea have announced.

It’s no big surprise, and it’s no huge achievement, but the scientists say they created the three clones of Snuppy to “immortalize” the “milestone” Snuppy represented — and that the clones will allow them to further study the lifespan of cloned dogs.

Snuppy, who spent most of his life in a laboratory, died at age 10 in April 2015.

“Three healthy reclones of Snuppy are alive, and as with Snuppy we do not anticipate that the reclones will go through an accelerated rate of aging or will be more prone to develop diseases than naturally bred animals,” the team wrote in Scientific Reports, a journal from the publishers of Nature.

To create the new clones, the scientists used fat-derived stem cells taken from Snuppy when he was five years old.

The stem cells were taken from his belly fat and frozen. Years later, they were thawed, grown in culture and then injected into enucleated eggs taken from female donors. The reconstituted eggs were then zapped with an electrical shock to fuse the membranes of the egg and stem cells. Ninety-four of them were transferred to surrogate female dogs.

Four resulted in births, but one of the pups died four days after it was born from severe diarrhea, the scientists reported.

The three remaining dogs will also live their lives in the lab, being monitored and undergoing tests the scientist say they suspect will dispel the notion that cloned animals die early deaths.

They say the second generation of Snuppy clones will contribute to a “new era” in the study of the health and longevity of cloned animals, and that they might contribute to cures being found for human diseases.

But with dog cloning having become big business — and having been initially researched with profits in mind — it’s no surprise that the latest research, funded in part by the Korean government, aims to dispel the thinking that clones live abbreviated lives.

Snuppy’s birth came eight years after Dolly the sheep became the first cloned mammal in 1997. Dolly died prematurely, at age six.

Snuppy

Snuppy

When Snuppy was born in 2005, Time magazine named him one of the most amazing inventions of the year. What wasn’t reported much, at least not initially, were the intrusive procedures involved, the birth defects that resulted, the surplus dogs that resulted, and the long list of animal welfare concerns about the process.

In the article written in Scientific Reports, by the researchers involved, those concerns also get short shrift.

“Animal cloning has gained popularity as a method to produce genetically identical animals or superior animals for research or industrial uses,” they write.

“There is lots of pet cloning going on right now. Owners are concerned whether their clones will live (a normal lifespan) or if they will experience accelerated aging and die early. So, there is some business concern,” said said co-author of the study CheMyong Jay Ko, of the University of Illinois.

The clones of Snuppy might also provide insights into the development of cancer and other diseases, Ko said.

(Top photo from the National Post; bottom of photo by John Woestendiek)

To read more about the birth of dog cloning and how it became a big business, read John Woestendiek’s book, “Dog, Inc.

Chinese lab produces what it says is the world’s first “superdog” clone

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Chinese scientists say they have produced a “superdog” clone — and that the technology will enable them to mass produce dogs that are extra strong and extra fast.

And, unless you are a fan of the doggy version of eugenics, you might find that extra scary.

The beagle, named Long Long, was born in May, becoming one of China’s first canine clones and, the scientist’s maintain, the world’s first genetically modified canine clone.

“This is a breakthrough, marking China as only the second country in the world to independently master dog-somatic clone technology, after South Korea,” said Lai Liangxue, a researcher of Guangzhou Institute of Biological Medicine and Health with the Chinese Academy of Science.

The beagle puppy was genetically engineered by deleting a gene called myostatin, giving him double the muscle mass of a normal beagle.

longlongHe was one of 27 puppies created at Sino Gene, a biotech company based in Beijing — all clones of a laboratory research dog named Apple, according to published reports.

The researchers created 65 embryos through cloning, and genetically modified all of them.

Only Long Long had his myostatin deleted.

By combining genetic editing and cloning, scientists say they can produce “superbreeds” that are stronger and faster.

“With this technology, by selecting a certain gene of the dog, we can breed an animal with more muscles, better sense of smell and stronger running ability, which is good for hunting and police applications,” Lai said.

He also suggested that the gene-editing technology could be commercialized and further applied to create dogs with diseases such as autism, Parkinson’s and diabetes, for use in medical research.

It’s just the latest chapter in dog cloning, which has a frightening history and, potentially, an even scarier future.

Efforts to clone dog began in the U.S., with early research at Texas A&M funded by backers who saw cloning people’s pets — often sick, dying or even dead — as a profitable business enterprise.

Canine cloning wasn’t achieved until a few years later at Seoul National University in South Korea when Snuppy, the world’s first canine clone, was born in 2005.

The service would be offered to pet owners by several businesses, only one of which remains, Sooam Bioengineering Research Institute, the laboratory of controversial South Korean scientist Hwang Woo Suk.

longlong2Twelve years would pass before China became the second country to clone dogs — and clone them with a twist.

Lai says his team will be able to “batch produce” customized dogs through cloning and gene-editing, which in addition to possible military and law enforcement uses, would create an endless supply of dogs for use in laboratories by medical researchers.

The researcher has worked for years on genetically modifying dogs. By mastering cloning, and combining it with his gene-editing, he’s able to endlessly duplicate any successes he achieves.

As with Dolly the sheep and Snuppy the dog, Lai’s achievement is seen as ominous by some.

“It’s true that the more and more animals that are genetically engineered using these techniques brings us closer to the possibility of genetic engineering of humans,” David King, director of Human Genetics Alert, told the Express..

“That does set us on the road to eugenics,” King added. “I am very concerned with what I’m seeing.”

Me, too. Dog cloning raises some significant animal welfare concerns. Technology, especially when coupled with greed or ego, tends to run amok. Eugenics is a nightmarish pursuit, as is its canine version. Creating diseased dogs for medical research is just plain wrong.

On top of all that, this latest twist being touted by the Chinese researchers fails to recognize one simple fact:

Dogs are already super.

(Photos: Sino Gene)

A funny — and life-saving — thing happened on the way to the slaughterhouse

jindolThe four new arrivals at the Watauga Humane Society, a no-kill shelter nestled in the hills outside Boone, N.C., started adapting to their new lives not long after they were removed from a farm south of Seoul, Korea.

They continued to grow a little less timid and fearful of humans while they were quarantined in a sanctuary there, flown to the U.S., driven hundreds of miles to five different shelters and quarantined again.

Soon, they’ll be making the final step on the way to becoming pets, instead of meat.

twopartsThe four are among 31 dogs from Korea who arrived at no-kill shelters in North Carolina last week to be put up for adoption.

And those 31 are among 525 who have come to the U.S. and Canada since the beginning of last year, when Humane Society International added a new strategy to its campaign to bring an end to dog farms in Korea — closing them down one farm at a time.

Representatives of HSI, working with local animal activists in South Korea, have succeeded in shutting down five farms since then — usually by negotiating deals with the farmers and persuading them to pursue new, less brutal livelihoods.

One dog farm became a blueberry farm. Another switched from raising dogs to growing chili peppers. One dog farmer agreed to stop dog farming and, with help from HSI, started a water delivery business.

It’s only a small dent, given there are thousands of dog farms in South Korea, some with 1,000 dogs or more, all being raised to be sold for their meat.

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They are commonly abused and neglected and spend their lives in crates before being sold to markets, where things get even crueler.

Farm dogs are sometimes boiled alive, sometimes beaten before slaughter under the belief that it makes their meat more flavorful. Their meat is sold to individuals and restaurants at open air markets, where you can pick a live one for butchering.

It’s all a perfectly legal tradition under laws in Korea, where a minority of the population still eats dogs, and many believe the meat offers health benefits, particularly in the summer months.

That minority is shrinking more as younger Koreans turn away from the practice, a fledgling animal welfare movement grows and the perception of dogs as family members becomes more widespread.

Perhaps, South Korea will, in time, outgrow the practice. Perhaps the Olympics coming to Seoul in 2018 — as it did in 1988 — will lead government officials, who did their best to hide it then, to take more meaningful steps.

Until then, animal activists — locally and globally — do what they can.

My first exposure to dog farms was seven years ago, when I went to South Korea to research a book I was writing on dog cloning. On the road to achieving that “feat,” researchers regularly bought and borrowed meat dogs from farms, using them for experiments, to help clone the first canine and to clone the dogs of pet-owning customers once the practice hit the marketplace.

I ended up at Moran Market — and quickly wished I hadn’t.

Images of what I saw then still pop up in my head, unasked. I’ll spare you the graphic details.

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It is estimated that more than 2 million dogs are slaughtered for human consumption in South Korea each year.

Add in those consumed in China, Vietnam and other Asian countries, and as many as 30 million dogs a year are killed for their meat.

South Korea is the only country where the practice has been industrialized. The New York Times reported in May that government data show there are more than 17,000 dog farms.

The Humane Society program is an attempt to shine a light on the issue, while also giving at least a few of the dogs a chance. On top of that, it strives to show that farm dogs, stigmatized in Korea and often perceived as different from pet dogs, are one and the same.

In one of the largest agreements brokered so far, this past May, a dog farmer in Wonju turned over all 260 of the dogs he was raising — mostly on discarded scraps he collected from restaurants — in exchange for certain considerations.

The particulars of the deal weren’t announced, but HSI offers incentives to farmers — $2,000 to $60,000 depending on the number of dogs involved — who agree to forfeit their dogs and get out of the business.

That farmer, Gong In-young, told the New York Times that many of the dogs were just weeks away from being sent to the slaughterhouse.

Gong, in addition to his farm dogs, had a pet dog, too. Asked about the difference in the lives of his farm dogs and his own dog, a spitz named Snow White, he described it as “the difference between heaven and hell.”

The most recent batch of dogs transported to the U.S. by HSI was small by comparison.

The dogs lived on a small farm in Jeonju, about 120 miles south of Seoul. A Canadian organization, Free Korean Dogs, was tipped off about it by local activists and, upon further investigation, learned it was an illegal operation.

While dog farms are legal, this farmer and his dogs were squatters, occupying land that didn’t belong to him. Law enforcement authorities were contacted and ordered the farmer and the dogs off the land.

That left the farmer willing to negotiate, and he eventually agreed to turn all 30-plus dogs over to a sanctuary at the end of July.

HSI, working with Free Korean Dogs, then took steps to have them shipped to the U.S., making arrangements for them to be taken in and adopted out by no-kill shelters who participate in the Humane Society’s Emergency Placement Partners program.

Those who participate in the program accept dogs the Humane Society has rescued — from everything from puppy mills to natural disasters.

All 31 farm dogs, after their flight and a few days in Maryland, were brought to shelters in North Carolina.

In the parking lot of a shopping center in Cary, the dogs were turned over to volunteers from local humane societies and shelters in the state, the News & Observer reported.

Those shelters included Cashiers Highlands Humane Society, Paws of Bryson City, Moore Humane Society in Carthage, Outer Banks SPCA in Manteo, and the Watauga Humane Society in Boone.

I visited the four who went to Boone last week.

I wanted to take some photos. I wanted to see how anti-social and fearful of humans they might be, or if that resilience dogs are famous for was already becoming apparent.

I wanted to understand how hard it might be for them to shake the past. Many who have adopted them say they’ve gone on to make greats pets — as has been the case with many of Michael Vick’s fighting dogs, puppy mill dogs and other dogs who have seen and suffered from the worst in humans.

And in the back of my head, which is also where those images of meat market dogs linger, I was thinking I might like to have one.

(For part two of this story, click here.)

(Photos: From top to bottom, Jindol, one of the four Korean dogs now at the Watauga Humane Society, by John Woestendiek; caged dogs at a South Korean dog farm, by Jean Chung for The New York Times; dogs awaiting butchering at Moran Market in Seoul, by John Woestendiek)