A new medication that claims to soothe dogs who are frightened by loud noises, such as fireworks and thunderstorms, will be available to veterinarians in the U.S. within a week — in plenty of time to help make the 4th of July less traumatic.
Sileo (not a very serious sounding name, is it?) comes in a gel form and is the first prescription medicine for treating anxiety over loud noises in canines– a widespread problem that leads to property destruction, running away and life-threatening injuries.
Its U.S. maker, Zoetis of Florham Park, New Jersey, says Sileo (pronounced SILL-lee-oh) works by blocking norepinephrine, a brain chemical similar to adrenaline that pumps up anxiety.
It is applied to a dog’s gums via a pre-filled, needle-less syringe.
Zoetis says the medication will give owners of the estimated third of the 70 million dogs in the U.S. who have problems with loud noises an alternative to human anti-anxiety pills, like Xanax, that sedate dogs for many hours.
Sileo takes effect within 30 minutes to an hour.
The pre-filled applicator costs $30, and contains enough for two doses for a dog of 80 to 100 pounds, four doses for a 40-pound dog, or six doses for a small dog.
Dogs can be re-dosed every two hours, up to five times during each noise event, Zoetis said in a press release.
Zoetis has exclusive rights to distribute Sileo in the U.S. under an agreement with the medication’s developer, Orion Corp. of Finland.
In testing on 182 pet beagles conducted on New Year’s Eve, 75 percent of their owners rated its effect good or excellent. Side effects were rare and minor, the company says.
(Photo: Provided by Zoetis)
Posted by John Woestendiek May 17th, 2016 under Muttsblog.
Tags: 4th of July, animals, anxiety, behavior, canine, dog, dogs, drugs, fear, fireworks, first, fourth of july, gel, july 4, loud, medication, medicine, new years, noise, noises, pets, prescription, sileo, syringe, thunderstorms, veterinarian, veterinary, zoetis
Police arrested Heather Pereira, of Elizabethtown, during a visit to her veterinarian’s office and charged her with three counts of animal torture and obtaining a controlled substance by fraud. She was being held this week at the Hardin County Detention Center on a $5,000 bond.
It was the veterinarian’s office that contacted authorities after Pereira brought her dog in three times in three months for treatment of lacerations. Each time, Pereira asked for the powerful pain medication Tramadol for the dog, a golden retriever.
“Typically, as veterinarians, we see the best of people, people rescuing unwanted pets, people rescuing pets that have been hit on the street,” veterinarian Dr. Chad Bailey with Elizabethtown Animal Hospital said in an interview with WLKY. “Something like this is definitely uncharted territory,” Bailey said.
Pereira, 23, brought her dog to the hospital twice in October for treatment of mulitiple lacerations. On Dec. 4, the dog returned with more cuts and vets suspected, based on “the cleanliness of the cuts,” that they were inflicted with a razor, possibly intentionally.
Police were called and began an investigation, during which Pereira confessed she was injuring the dog to obtain pain medications.
“It was determined she was actually taking them and using those medications for herself instead of for the dog,” said Elizabethtown Police Sgt. Timothy Cleary.
At one point, police said, Pereira told vets she needed more painkillers for the dog because her child had flushed them down the toilet.
Pereira doesn’t have any children.
The dog has been removed from her home and placed in foster care. She’s going by a new name — Alice.
“She’s a great dog, wagging her tail, and, you know, I’m sure the dog has already forgiven, that’s just what dogs do. They love us unconditionally, and she’s a great dog and doing fine,” Bailey said.
Posted by John Woestendiek December 11th, 2014 under Muttsblog.
Tags: abuse, abusing, animals, arrest, chad bailey, controlled substance, cuts, dog, dogs, drugs, elizabethtown, elizabethtown animal hospital, golden retriever, hardin county, heather pereira, injuries, kentucky, lacerations, medication, owner, pain killers, painkiller, painkillers, pets, police, taking, torture, tramadol, vet, veterinarian, veterinary
Two University of Washington scientists think it might be possible to slow the aging process in canines and are launching a pilot study with 30 dogs to see if the drug rapamycin significantly extends their lifespans.
The researchers, using $200,000 in seed money from the University of Washington, plan to use pets, not laboratory animals, for the initial study, and recruit volunteer dogs — or at least dogs whose owners volunteer them — for larger scale studies in the future.
Daniel Promislow, an evolutionary geneticist, and Matthew Kaeberlein, a molecular biologist, say the study is aimed at determining whether rapamycin could lead to longer lives for dogs — as studies have shown is the case when it’s used on yeast, fruit flies, worms and mice.
“We’re not talking about doubling the healthy life spans of pets,” said Kaeberlein. “But at a minimum I would predict that you would get a 10 to 15 percent increase in average life span, and I think bigger effects are possible.”
In the pilot study, 30 large, middle-aged dogs will be involved — half receiving low doses of rapamycin, half receiving placebos.
The researchers say that subsequent studies will seek to enroll pet dogs from across the country.
Kaeberlein and Promislow hosted a meeting in Seattle last week where experts from across the country discussed the drug rapamycin and its possible effects on the health and longevity of dogs, the Seattle Times reported.
Currently used along with other medications to prevent rejection in organ-transplant patients, rapamycin has been called a promising anti-aging drug — though there have been no studies involving humans.
But almost 50 laboratory studies have shown that the compound can delay the onset of some diseases and degenerative processes and restore vigor to elderly animals, extending life spans by 9 to 40 percent.
Rapamycin functions, in part, by inactivating a protein that promotes cell growth. As a result, cells grow more slowly, which retards the spread of cancer.
Promislow, who has two elderly dogs of his own, noted that even if the drug doesn’t increase the life span of dogs, it could serve to keep them healthy longer. “We’re trying to understand why some dogs age better than others, and help all dogs age in a better way,” he said.
The drug has been shown to have serious side effects, including poor wound healing and an increased risk of diabetes, when used at the high doses required for organ transplant patients.
But the low doses used in anti-aging research with mice and other lab animals cause few side effects.
There have been no large-scale human trials. Studying how the drug affects dogs — who suffer many of the same old-age ailments as their masters — makes it possible to explore the possible benefits of rapamycin both more quickly and at a lesser cost.
If it does turn out to be a sort of fountain of youth — for dogs, humans, or both — the potential profits would be enormous.
“I think it’s worth a go, not just from what it can teach us about humans, but for the sake of the animals themselves,” said University of Alabama Biology Department Chairman Steven Austad, an expert in aging research who is not involved in the project. “It may not work in dogs, but if it did, boy, it’s going to be huge.”
According to the Seattle Times article, drug companies aren’t very interested in rapamycin because it’s no longer under patent.
But the researchers are hoping dog lovers, dog-food companies and some foundations might be willing to contribute to further research.
They’ve set up a website, dogagingproject.com,where people can donate and sign their dogs up to take part in the research.
“Given how I feel about my pets, I see this as a unique project where there’s a real potential for citizen science,” Kaeberlein said. “I think it would be great if pet owners who are really interested in improving the health of their animals would help fund this work.”
(Photos: UW scientists Matt Kaeberlein, with his dog Dobby, and Dan Promislow, with his dog Frisbee; by Steve Ringman / The Seattle Times)
Posted by John Woestendiek November 4th, 2014 under Muttsblog.
Tags: animals, anti aging, anti aging drug, biology, cancer, cells, citizen science, compound, Daniel Promislow, death, dog, dogs, drug, drugs, extending, fountain of youth, funding, geneticist, health, ifespan, laboratory, life, lifespans, lives, longer, Matthew Kaeberlein, molecular, pets, rapamycin, research, sickness, study, university of washington
A Houston man who once portrayed McGruff the Crime Dog has been sentenced to more than 16 years in prison on drugs and weapons charges.
John R. Morales was sentenced to federal prison last week for charges related to his 2011 arrest.
Police who raided Morales’ residence then seized 1,000 marijuana plants and 9,000 rounds of ammunition for 27 weapons — including a shotgun, pistols, rifles, and a military grenade launcher, according to court documents obtained by NBC.
What does all this prove? If you want mascot who is pure, ethical and beyond reproach, choose a real dog. They are far less likely to get arrested, far less likely to cause a scandal, and far less likely to cave in to temptation, unless they are of the bacon variety.
This wasn’t the first time the choice of a human to play McGruff has come back to bite law enforcement. There was an incident in Phoenix in 1998 when a prison trusty police assigned to play the role removed his head and was recognized by parents in the audience as a convicted child molester.
Morales wore the McGruff costume for the Harris County Sheriff’s Association in the late 1990s. Fox News reported.
The human-like, trench coat-wearing dog was created by the global advertising agency Saatchi & Saatchi through the Ad Council for the National Crime Prevention Council to increase crime awareness among children.
He appeared on television in animated form, and in public appearances he was portrayed by actors wearing the giant dog head and costume.
He urged young people to “take a bite out of crime.”
Morales, after his McGruff gig, was stopped in 2011 by police in Galveston for speeding, and marijuana was detected in his car trunk. Authorities said that, in addition to marijuana plants, they found a clipboard with diagrams of two indoor pot farms in his car.
That led officers to a stash of 1,000 marijuana plants and the weapons.
And who was it that first detected the marijuana in the car? A real police dog.
Posted by John Woestendiek February 10th, 2014 under Muttsblog.
Tags: actor, ad council, anti crime, arrest, awareness, character, costume, crime, crime dog, crime prevention, drugs, embarassment, houston, marijuana, mascot, mcgruff, mcgruff the crime dog, take a bite out of crime, weapons
What’s a working dog to do? You learn your trade, hone your skills, toil away, only to find out that the world around you has evolved to a point where those skills are no longer much appreciated.
It’s why you can’t find a blacksmith too easily nowadays. It’s what happened to the elevator operator, the milkman, and, at least from my biased and disgruntled point of view, the newspaper reporter.
Such too was the case with Phelan, a marijuana-detecting Labrador retriever in the employ of the police department in Lakewood, Colorado.
With the passage by Colorado voters of Initiative 502 — legalizing the recreational use of small amounts of marijuana — the skill Phelan was best known for is no longer much in demand there.
In fact, his biggest asset has become a liability, the News Tribune reports.
Phelan was handed his pink slip this week and sold to the state Department of Corrections, where, in his new job, his inability to distinguish between marijuana and other drugs won’t be a problem — all drugs being illegal behind bars.
The same story is playing out in Washington state, where voters also legalized marijuana use, and where police departments are figuring out whether to cease training new dogs in marijuana detection, put their existing dogs through “pot desensitization” training or just retire them and send them out to pasture, according to the Associated Press.
Take it from me, pasture sucks. Dogs and people, I think, prefer having a mission.
But Phelan’s mission, at least in the two states where moderate amounts of marijuana are now permitted, no longer much needs to be accomplished. Worse yet, alerting to small amounts of marijuana could mess up prosecutions in cases involving other, still illegal, drugs.
Say Phelan alerted to drugs in the trunk of a car. Phelan’s inability to distinguish between heroin and marijuana — or at least specify to his handler to which he is alerting — means any subsequent search by officers could have been based on Phelan detecting an entirely legal drug, in an entirely legal amount.
That means the “probable cause” the search was based on might not have really existed, and that means any evidence of illegal drugs subsequently found in the search would likely be tossed out.
Thus Phelan, unless he were to be retrained to drop marijuana-detecting from his repertoire — not easily accomplished — has ended up going from cutting edge law enforcement tool to an old school has been.
Drug detecting dogs — traditionally trained to alert to the smell of marijuana, heroin, crack cocaine, methamphetamine and cocaine — can’t specify what they’re smelling, much less the quantity it might be in.
In Washington, the new law decriminalized possession of up to an ounce of the drug for individuals over 21, and barred the growth and distribution of marijuana outside the state-approved system.
Dog trainer Fred Helfers, of the Pacific Northwest Detection Dog Association, said abandoning pot training is a “knee-jerk” reaction: “What about trafficking? What about people who have more than an ounce?” Still, he’s helping departments who want to put their dogs through “extinction training” to change what substances dogs alert to. That takes about 30 days, followed by a prolonged period of reinforcement.
The Washington State Criminal Justice Training Commission removed detecting marijuana from its canine team certification standards this year, and no longer requires dogs be trained to detect it, but some others say, given large amounts of pot are still illegal, it can still be a useful skill for a dog to have.
In Pierce County, prosecutor Mark Lindquist believes new dogs are the answer — dogs trained in sniffing out the other drugs, but not marijuana. He’s not convinced dogs can be re-trained. “We’ll need new dogs to alert on substances that are illegal,” he told the Associated Press.
Other police departments, like Tacoma’s, aren’t making any changes.
“The dog doesn’t make the arrest, the officer does,” said spokesperson Loretta Cool. “A canine alert is just one piece of evidence an officer considers when determining whether a crime has been committed.”
Phelan was one of two drug-sniffing dogs on the police force in Lakewood, Colorado. He’ll be replaced by Kira, a Belgian Malinois who was trained not to alert when she smells marijuana. Duke, a Labrador retriever mix with the old-school training, will remain on the force for now.
Phelan, though, will be moving on, and I sympathize with the crime-fighting Lab.
His new gig in the slammer is clearly a step down the career ladder — not unlike going from being a newspaper reporter detecting corruption and injustice to an unpaid blogger who mostly (but not entirely) regurgitates material already written.
And, for Phelan, there’s the added insult of being sold for the lowly sum of one dollar.
Surely — old school as his talents may be — he was worth more than that.
Posted by John Woestendiek June 12th, 2013 under Muttsblog.
Tags: alert, cocaine, colorado, court, criminal justice, detect, detection, dog, dogs, drug-sniffing, drugs, heroin, job, K-9, k9, lakewood, law, law enforcement, marijuana, marijuana laws, mission, newspapers, police, police dogs, problems, prosecutors, purpose, reporters, searches, skills, sniffing, tacoma, useless, washington, working dogs
This ad for Trifexis depicts a dog living in a bubble — albeit it one that’s outside and has plenty of tubes to run around in.
It serves to protect him from heartworms, hookworms, roundworms, whipworms, flea infestations and all those other frightening hazards that exist in that place where dogs, for centuries, managed to survive:
What we find most interesting about it, though, are the disclaimers, which seem to have risen with doggie prescription drugs to the same level they have with human ones, where three-fourths of the advertisement are devoted to a listing of potential scary side effects, quickly recited in monotone, in hopes you — or your dog — won’t really hear them.
With Trifexis, it goes like this: “Treatment with fewer than three monthly doses after the last exposure to mosoquitoes may not provide complete heartworm prevention. The most common adverse reactions were vomiting, itching and lethargy. Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis.”
On top of the warnings recited, more appear in small print during the ad:
“To ensure parasite protection, observe your dog for one hour after administration.”
“If vomiting occurs within an hour of administration, give another full dose.”
“Puppies less than 14 weeks of age may experience a higher rate of vomiting.”
In their print ads, the makers of Trifexis additionally advise the drug be used with caution in breeding females, and in dogs with epilepsy. Its use in breeding males has not been evaluated. Print ads also list lethargy, depression, decreased appetite and diarrhea as possible side effects.
The chewable, beef-flavored tablets — administered once a month — are a combination of spinosad and milbemycin oxime, and they serve to prevent heartworm disease, kill fleas and prevent infestations and treat hookworm, roundworm and whipworm infections.
The tagline for the ad is “You don’t have to go to extremes to protect your dog from parasites.”
Apparently you do, though, if you’re selling prescription drugs — for canines or humans — to protect your ass from lawsuits.
To see all our “Woof in Advertising” posts, click here.
Posted by John Woestendiek May 21st, 2013 under Muttsblog, videos.
Tags: animals, appetite, bubble, canine, caution, chewable, depression, diarrhea, disclaimers, disease, dog, dogs, drugs, environment, fleas, health, heartworm, hookworm, human, infections, itching, lethargy, loss, mosquitoes, parasites, pets, prescription, prevention, protection, roundworm, safety, side effects, tablets, trifexis, tube, veterinarians, veterinary, vomiting, warning, whipworm
Ralph Ullum, 68 of Claysville, was attending a kennel club show in December at the DuPage County Fairgrounds with his girlfriend, whose Siberian husky, Diana, was entered in the competition.
He’s accused of feeding Protonix and possibly Benadryl to a competing husky, named Pixie, NBC in Chicago reported.
Pixie’s handler, Jessica Plourde of Newark Valley, N.Y., noticed a crushed pink pill near Pixie’s cage on the second day of competition, according to police. Later, witnesses came forward saying they had seen Ullum feeding and petting Pixie while Plourde was away from the cage
A veterinarian induced vomiting in Pixie and found a rubber band, dog food, chicken pieces and an undigested Protonix pill. Protonix is used to treat acid reflux and heartburn. Wheaton police say the pink crushed pill found near Pixie’s cage is believed to be Benadryl, an over the counter allergy medicine that can cause drowsiness.
Ullum denied feeding anything to Pixie, but said he did pet her.
His hearing on misdemeanor cruelty to animals charges is scheduled for June.
Posted by John Woestendiek April 30th, 2011 under Muttsblog.
Tags: animal cruelty, animals, arrest, benadryl, cheating, competition, competitors, diana, dog, dog show, dog shows, dogs, drugged, drugging, drugs, dupage county, kennel club, pennsylvania, pets, pixie, protonix, purebreds, ralph ullum, sabotage, siberian husky, wheaton