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Tag: drugs

Chinese scientists clone dogs with heart disease — and call it an achievement

longlong

China says it has managed to join South Korea as a world leader in canine cloning — by managing to create a clone of a sick dog.

Longlong, a beagle, was born with a blood-clotting disorder, and that was just what the scientists were hoping for.

The pup is a clone of Apple, a different dog whose genome was edited to develop the disease atherosclerosis, CNN reported.

longlong1By cloning the bioengineered dog, the scientists ensured they will have a good supply of diseased dogs for experiments they say could lead to cures for the condition that causes strokes and heart disease in humans.

Longlong was created by the Beijing-based biotech company Sinogene, which is boasting about having created the world’s first dog cloned from a gene-edited donor.

With Longlong’s birth, and two more clones of the bio-engineered dog being born since then, the scientists claimed that China had matched South Korea as a leader in canine cloning technology. South Korean scientists cloned the first dog, an Afghan hound named Snuppy, in 2005.

“Dogs share the most inheritable diseases with human beings, which makes them the best disease models to study,” says Feng Chong, technical director at Sinogene.

While the pups haven’t shown any signs of cardiovascular disease yet, their cloning ensures they will get it. Experimental drugs to treat cardiovascular diseases are already being tested on them.

Longlong’s birth combined two technologies: A gene-editing tool called CRISPR with somatic cell cloning technology, the method used to clone Dolly the sheep and later, Snuppy.

Zhao Jianping, vice manager of Sinogene, says the company’s success in dog cloning is about 50%. Two surrogate dogs out of four gave birth to three cloned puppies. The other two did not get pregnant.

Scientists at Sinogene believe their work aids the future of pharmaceutical development and biomedical research and it plans to produce more cloned dogs like Longlong.

“Gene-edited dogs are very useful for pharmaceutical companies,” said Feng. “The supply falls short of the demand every year.”

(Poor little pharmaceutical companies.)

The scientists also say cloning bio-engineered dogs to create puppy clones that will be born with the disease is kinder than the previous method of creating atherosclerosis in lab dogs — namely, force feeding with meals high in sugar.

Scientists, in case you haven’t noticed, have also invented a way to justify just about anything they want to do.

So if you want to hail this as a great achievement in technology, go ahead. I prefer to see it as scientists taking another giant stride toward playing God — giveth-ing life to dogs, only to taketh it away. Mankind may benefit (or at least live a longlong time), but rest assured the biggest gains will go to pharmaceutical companies.

(Photos: CNN)

Ruh-roh: Scooby-Doo dog treats end up on the human cookie aisle in Australia

scoobsnack

You’d think that — even on the cookie aisle — a mother would think twice before tossing a bag of Scooby Snacks into her grocery cart for the kids.

You’d think that the picture of the famous cartoon dog on the package, and the words “pet food only,” would have given her a clue.

You’d think that, as she loaded the bone-shaped treats into her children’s lunch boxes, she’d realize something was amiss.

But it wasn’t until the kids got home from school and told her they didn’t like the new “choc friendly carob” treats — “yuck, they are disgusting,” they said — that she gave the package a closer look.

That’s when she finally saw they were not only labeled as dog treats but that they promoted “skin and coat health.”

“On closer inspection they are DOG treats,” Tania Toomey, of Sydney, Australia, admitted on Facebook. “It does say that it is pet food only – human friendly but not recommended!”

But she added, “BE CAREFUL the store is very disorganised … Terrible and disgraceful, not to mention dangerous!” she wrote on the store’s Facebook page.

Before we pounce too hard on grocery store management — or the stoner stock boy we imagine was behind the error — consider this.

There are Scooby Snacks for dogs AND Scooby treats for humans, not too mention some other slang applications of the term to describe — Zoinks! — certain illicit drugs.

keeblerscoobygrahamKeebler, a Kellogg’s company, makes bone-shaped Scooby Doo Graham Cracker Sticks for humans, and they come in a box with Scooby pictured on the front.

Betty Crocker, a General Mills company, offers Scooby-Doo Fruit Flavored Snacks — for humans. They come in a box with a big picture of Scooby on the front.

Del Monte makes a version of its dog treat Snausages that goes under the name Scooby Snacks.

Confused? As a rule, if something is called Scooby Snacks (without the “doo”) it is probably a dog snack. If the full name of the dog is used — both the the “Scooby” and the “Doo” — it is likely a human snack, even if it is shaped like a bone and has a large picture of a dog on the box.

Still confused? Well, we all are, but do be careful when asking for Scooby Snacks, because the phrase can also apply to Valium, Vicodin, Quaaludes, and hash or marijuana brownies, according to Urban Dictionary.

Scooby Snacks, in the cartoon show, were consumed by dog and human alike. Some of the show’s cult members/fans are convinced they were actually (well, as “actually” as things can get in a cartoon) weed or hash brownies.

They seemed to be a common solution to many of the problems Scooby and the gang came across. They made everything work out — or at least kept Shaggy and Scooby on an even keel.

We should point out here that dog treats of any type aren’t generally harmful to children or other humans, and that until the makers of rat poisons start appropriating Scooby’s name and image, we are probably safe.

Since the story of the Sydney mom hit social media, many others have admitted to accidentally consuming the dog treats — in Australia, New Zealand and elsewhere.

A father-of-two from the northern beaches in Sydney bought the dog treats for his young boys. He told news.com.au that the dog treats were incorrectly placed in the snack aisle of his local Woolworth’s and he grabbed them quickly without looking at the packet.

groceryaisleAnother posted a photo of Scooby Snacks for dogs clearly pictured next to packets of human snacks in a grocery store.

Woolworths initially stated that the pet food product was only stocked in the pet food aisle.

Then, store officials admitted that a mix-up had occurred and apologized for it.

Comments from social media users indicate that Scooby-labeled snacks have created confusion among many customers and at more than a few stores.

And in their comments, as always, they’re feeling free to pass judgment.

Some social media users have defended the mother as a victim of grocery store error.

Some have pointed out the product is clearly marked as a dog treat and say the mother should have been a little more alert.

Others have inquired as to whether her children have taken to digging in the back yard or scratching behind their ears.

It’s getting harder to fetch this stick

quicksand

(Today’s post has nothing to do with dogs. This happens on rare occasion when I become so steamed about some non-dog issue that I must vent — today in the form of a fable.)

You are hiking down a remote jungle trail in some country where there is quicksand — that legendary kind of quicksand from which there is no escape — when you come across a woman who is hip deep and sinking slowly.

“Oh thank God,” she says when she sees you.

She looks familiar. You smile and ask her name.

“Heather Bresch,” she says.

It takes a moment to register. “Heather Bresch? The CEO of Mylan, the pharmaceutical company that makes the EpiPen?”

“Yes,” she says as she struggles against the quicksand and sinks a little deeper. “I’m vacationing in this country, and I left my luxury villa to take a little walk and this happened. I need help.”

“Clearly you do,” you say. “I’m happy to provide assistance.”

“If you could get that fallen tree limb over there and pass it to me, I think I could pull myself out,” she says, sinking up to the waist as she points.

You walk over and pick up one end of it. “This one?” you say.

“Yes,” she says. “Hurry please.”

You begin sliding the tree limb in her direction.

“This one is $10 million,” you say.

She laughs uncomfortably. “Please, hurry,” she says.

“I’m serious,” you say.

“That’s ridiculous,” she says. “It’s just a tree limb.”

epi“And the EpiPen is just a stick with, or so I’ve read, $1 worth of medicine in it — yet your company has raised the price of it to $300.”

“The EpiPen save lives,” she says.

“So might this stick, if used as directed,” you respond.

Up to her chest in quicksand, she promises to give you the money when she gets out, but you tell her you need it up front.

She struggles to dig into her pockets, causing her to sink up to her neck. As she pulls cash out of her pockets and flings it in your direction, she explains that the six-fold increase in the price of EpiPens was necessary.

“Mylan has spent millions on research and development of the product,” she says. “You can’t expect us to pay for all that ourselves.”

“Oh, so you invented Epinephrine?”

“Well, no, but we’ve spent a lot of money perfecting our sophisticated self-delivery system — in which you plunge a needle in your own leg and push down on the stopper, administering a pre-measured, life-saving dosage.”

“And if people just measured their own, and used an old fashioned syringe, what would be the actual cost?” you ask.

“Oh, maybe about $2.29, but that’s not the point. The point is much effort and significant expense went into creating that delivery system — things like shipping and handling and lobbying and designer white lab coats, all part of our noble effort to keep people from dying from allergic reactions to bee stings and such.”

She throws a final fistful of cash out of the quicksand. “There,” she says, “that’s $10 million. Now please slide that stick to me.”

“Oh, I’m so sorry,” you say. “The $10 million price was five minutes ago. It has gone up since then – to $20 million.”

“That’s more than I make in a year,” she protests.

bresch“Well, only 1 million more,” you point out. “The only thing that has climbed more quickly than the cost of EpiPens is your salary.”

“We are not talking about my salary,” she says. “Now, please, the stick. Anyone can hand someone a stick. It costs nothing.”

“Bear in mind,” you say, as the quicksand rises to her mouth, “you are not so much paying for the stick as you are paying for the delivery system. Just look at me as a monopoly providing a needed service. And the cool part is I just stumbled upon my monopoly. I didn’t need help from my senator-father, or to spend millions lobbying for it.”

You watch as the quicksand covers her nose, and then her eyes.

As the top of her head disappears, you plunge the stick into the muck. She grabs on and hauls herself out. Though coughing and exhausted, she manages a laugh, and you are pretty sure you hear her call you a “sucker.”

She crawls about picking up her money as you walk away — but not before noticing an anaconda is slithering up to her from behind, and an alligator is creeping towards her from the river, and a swarm of Zika-carrying mosquitoes is headed her way.

You are not worried about her. She is where she belongs:

With all the other predators.

Dog found high on meth gets new home


Bubba, a Jack Russell terrier-Chihuahua mix found high on methamphetamine in a seedy California hotel room four months ago, is headed to a new home.

No sooner was he pronounced healthy, drug free and available for adoption Wednesday than a couple walked into Orange County Animal Care and adopted the seven-month-old dog.

The couple, who had been following his story, asked not to be identified, though they did allow a photo to be taken of the new happy family.

Bubba had been at the shelter since March after being rescued by animal control officers from a drug-infested motel room in Tustin. He was only eight weeks old at the time.

Tests later show he had ingested methamphetamine and heroin.

His owner, Joshua West, 40, of Mission Viejo, was arrested on an outstanding warrant and suspicion of possession of methamphetamine, heroin and drug paraphernalia and booked into Orange County Jail.

Another southern California man was arrested last week after his Chihuahua, named Jack Sparrow, was found to have ingested methamphetamine.

After months of treatment, Bubba’s test results came back clear for the first time, prompting the shelter to put him up for adoption, according to Jennifer Hawkins, shelter director and chief veterinarian.

“They were a really nice couple and told us that Bubba would have a sister,” Katie Ingram, assistant director of OC Animal Care, told the Orange County Register. “Bubba bonded with them immediately.”

“It made it more meaningful that they were able to help him out because of his rough start in life,” Ingram added. “We were happy they are home quite a bit. It’s what he deserves.”

(Top photo by Mark Rightmire, Orange County Register; bottom photo courtesy of Orange County Animal Care)

Chihuahua on meth gets some help

jacksparrowWhen a veterinarian told a California dog owner that his suspicions were accurate, and his pet had indeed ingested methamphetamine, the owner turned down further treatment for the 10-year-old Chihuahua and left with his dog.

Given the dog, named Jack Sparrow, was in danger of dying, the vet contacted animal control, and the dog was seized from his owner to get the treatment he needed.

Police in Fontana said in a press release that Isaiah Nathaniel Sais walked into the Inland Valley Veterinary Specialists & Emergency Center in Upland on July 5.

saisSais, 21, told the vet he suspected Jack Sparrow had ingested methamphetamine after finding it in his house.

A urine test confirmed that to be the case, but when vets informed Sais of that, and of the treatment needed, he walked out with his dog.

Because doctors had observed Jack suffering from convulsions and seizures and felt Jack’s life was in jeopardy, they called Fontana Animal Services, which sent officers to the home of Sais.

They seized the dog from the owner after observing he was still convulsing and living in neglectful conditions.

“There was the smell of urine in his fur and his nails were over-grown,” Jaime Simmons, of Fontana Animal Services, told KTLA.

Officers suspected Jack may have been kept indoors for months.

Jack was taken back to the vet’s office, where he continues to recover, and is expected to be transferred into a temporary foster home in the next few days.

The case was immediately submitted to the San Bernardino Animal Cruelty Task Force and an arrest warrant issued for the owner.

Sais was being held at the West Valley Detention Center in San Bernardino on a felony animal cruelty charge.

New gel promises to make the 4th of July a less anxiety-filled time for dogs

sileo

A new medication that claims to soothe dogs who are frightened by loud noises, such as fireworks and thunderstorms, will be available to veterinarians in the U.S. within a week — in plenty of time to help make the 4th of July less traumatic.

Sileo (not a very serious sounding name, is it?) comes in a gel form and is the first prescription medicine for treating anxiety over loud noises in canines– a widespread problem that leads to property destruction, running away and life-threatening injuries.

Its U.S. maker, Zoetis of Florham Park, New Jersey, says Sileo (pronounced SILL-lee-oh) works by blocking norepinephrine, a brain chemical similar to adrenaline that pumps up anxiety.

It is applied to a dog’s gums via a pre-filled, needle-less syringe.

Zoetis says the medication will give owners of the estimated third of the 70 million dogs in the U.S. who have problems with loud noises an alternative to human anti-anxiety pills, like Xanax, that sedate dogs for many hours.

Sileo takes effect within 30 minutes to an hour.

The pre-filled applicator costs $30, and contains enough for two doses for a dog of 80 to 100 pounds, four doses for a 40-pound dog, or six doses for a small dog.

Dogs can be re-dosed every two hours, up to five times during each noise event, Zoetis said in a press release.

Zoetis has exclusive rights to distribute Sileo in the U.S. under an agreement with the medication’s developer, Orion Corp. of Finland.

In testing on 182 pet beagles conducted on New Year’s Eve, 75 percent of their owners rated its effect good or excellent. Side effects were rare and minor, the company says.

(Photo: Provided by Zoetis)

Woman used — and abused — her dog to score painkillers for herself, police say

pereiraA Kentucky woman has admitted to police that she injured her dog repeatedly to feed her own addiction to painkillers.

Police arrested Heather Pereira, of Elizabethtown, during a visit to her veterinarian’s office and charged her with three counts of animal torture and obtaining a controlled substance by fraud. She was being held this week at the Hardin County Detention Center on a $5,000 bond.

It was the veterinarian’s office that contacted authorities after Pereira brought her dog in three times in three months for treatment of lacerations. Each time, Pereira asked for the powerful pain medication Tramadol for the dog, a golden retriever.

“Typically, as veterinarians, we see the best of people, people rescuing unwanted pets, people rescuing pets that have been hit on the street,” veterinarian Dr. Chad Bailey with Elizabethtown Animal Hospital said in an interview with WLKY. “Something like this is definitely uncharted territory,” Bailey said.

Pereira, 23, brought her dog to the hospital twice in October for treatment of mulitiple lacerations. On Dec. 4, the dog returned with more cuts and vets suspected, based on “the cleanliness of the cuts,” that they were inflicted with a razor, possibly intentionally.

Police were called and began an investigation, during which Pereira confessed she was injuring the dog to obtain pain medications.

“It was determined she was actually taking them and using those medications for herself instead of for the dog,” said Elizabethtown Police Sgt. Timothy Cleary.

At one point, police said, Pereira told vets she needed more painkillers for the dog because her child had flushed them down the toilet.

Pereira doesn’t have any children.

The dog has been removed from her home and placed in foster care. She’s going by a new name — Alice.

“She’s a great dog, wagging her tail, and, you know, I’m sure the dog has already forgiven, that’s just what dogs do. They love us unconditionally, and she’s a great dog and doing fine,” Bailey said.