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Tag: first

New gel promises to make the 4th of July a less anxiety-filled time for dogs

sileo

A new medication that claims to soothe dogs who are frightened by loud noises, such as fireworks and thunderstorms, will be available to veterinarians in the U.S. within a week — in plenty of time to help make the 4th of July less traumatic.

Sileo (not a very serious sounding name, is it?) comes in a gel form and is the first prescription medicine for treating anxiety over loud noises in canines– a widespread problem that leads to property destruction, running away and life-threatening injuries.

Its U.S. maker, Zoetis of Florham Park, New Jersey, says Sileo (pronounced SILL-lee-oh) works by blocking norepinephrine, a brain chemical similar to adrenaline that pumps up anxiety.

It is applied to a dog’s gums via a pre-filled, needle-less syringe.

Zoetis says the medication will give owners of the estimated third of the 70 million dogs in the U.S. who have problems with loud noises an alternative to human anti-anxiety pills, like Xanax, that sedate dogs for many hours.

Sileo takes effect within 30 minutes to an hour.

The pre-filled applicator costs $30, and contains enough for two doses for a dog of 80 to 100 pounds, four doses for a 40-pound dog, or six doses for a small dog.

Dogs can be re-dosed every two hours, up to five times during each noise event, Zoetis said in a press release.

Zoetis has exclusive rights to distribute Sileo in the U.S. under an agreement with the medication’s developer, Orion Corp. of Finland.

In testing on 182 pet beagles conducted on New Year’s Eve, 75 percent of their owners rated its effect good or excellent. Side effects were rare and minor, the company says.

(Photo: Provided by Zoetis)

Dog and cheetah enjoy their first snowstorm

In case you’re needing to see some sort of silver lining behind those snow clouds that socked the eastern seaboard and paralyzed the northeast this weekend, we offer this.

Kago and Kumbali — a dog and cheetah who have become best friends at the Metro Richmond Zoo — got to play in the snow for the first time during winter storm Jonas.

The zoo was closed Saturday, but a zookeeper let the popular duo run and play in the 7-inch deep snow in a large fenced field.

kumbaliKumbali was two weeks old when caretakers at the zoo noticed he was losing weight. The runt of a litter born to zoo cheetahs Khari (the mom) and Hatari (the dad), Kumbali was bottle fed and grew healthier, but having been removed from his litter he needed some companionship.

So the zoo got him a dog.

Kago, a 10-week old Lab mix, had been pulled from a high kill shelter in Alabama by The Art of Paws, an animal rescue group in Florida.

Zoo officials report the two have become inseparable.

Kumbali and Kago can be seen at the zoo Monday to Thursday from 12 to 1 p.m., and on Friday and Saturday from 12 to 1 p.m. and 3 to 4 p.m. And you can find their full story here.

Here’s a look at their first meeting, and their younger (snowless) days:

(Photos and videos courtesy of the Metro Richmond Zoo)

World’s first in vitro puppies born at Cornell

ivf

Ten years after a dog was first successfully cloned, scientists have managed to produce the world’s first litter of pups to be born through in vitro fertilization.

In July seven puppies were born through IVF at Cornell University — five beagles and two “bockers,” or beagle-cocker spaniel mixes.

The achievement was not revealed until this week with the release of the research study.

Seems like science would have happened the other way around — that a “test-tube” puppy would have premiered long before we entered the even more science fiction-like era of cloned dogs becoming available on the marketplace.

But, while IVF has been used for decades in other animals, including humans, scientists had never succeeded in using it to produce a newborn pup.

Previous attempts to use IVF in dogs had resulted in very low rates of fertilization, and no live births at all once IVF embryos were transferred to a host.

“Since the mid-1970s, people have been trying to do [IVF] in a dog and have been unsuccessful,” said co-author Alex Travis, associate professor of reproductive biology at the Baker Institute for Animal Health in Cornell’s College of Veterinary Medicine.

What made it so difficult were some of the same factors that proved challenging in cloning dogs — females only ovulate once or twice a year, and their eggs are not transparent, making it harder to see the structures inside of the egg.

The Cornell researchers, in a joint project with researchers from the Smithsonian Institution, found that by waiting an extra day for eggs to mature before extracting them, they met with more success.

Adding magnesium to the environment where the sperm and egg met also helped with fertilization, the team found, according to a Cornell press release.

The achievement was revealed this week in a study published online Dec. 9 in the journal Public Library of Science ONE.

The seven surviving puppies (out of 19 embryos) are genetically the offspring of two different fathers (a cocker spaniel and a beagle) and three different beagle mothers, carried by the same beagle surrogate.

Unlike cloning, which involves transferring an existing (or dead) dog’s DNA into a donor egg, IVF involves the creation of a new genome through fertilization. Each each animal has a unique set of DNA.

The researchers say the development will open the door for preserving endangered canid species using assisted reproduction techniques.

It could also enable researchers to eradicate heritable diseases in dogs and facilitate the study of genetic diseases in dogs and humans, they say.

(Photo: Cornell graduate student Jennifer Nagashima and Smithsonian Conservation Biology Institute research biologist Nucharin Songsasen — lead author and co-author of the study — walk some of the puppies born through IVF; by Jeffrey MacMillan / Cornell University)

Second thoughts about dog cloning

SONY DSCOne of the men behind the push to clone dogs — and market the service to bereaved pet owners — seems more convinced than ever that doing so was, if not a mistake, at least a quest that led to some bad places.

Lou Hawthorne, who established a cell bank (Genetic Savings & Clone) and pushed researchers at Texas A&M University to try and clone the world’s first dog in the late 1990s — in hopes of turning dog cloning into a profitable business — said in an interview last week that cloning has led to thousands of dogs suffering each year.

“A cloned dog contributes to the happiness of a family but I do not think it is possible to do it without a huge amount of suffering to hundreds of others,” Hawthorne told The Mirror, which was reporting on the first dog cloning for a customer in the UK.

Hawthorne has been out of the dog cloning business since shutting down BioArts, the successor to Genetic Savings & Clone, which closed not long after efforts to clone a dog at Texas A&M were dropped.

That research was funded by John Sperling, the wealthy founder of the University of Phoenix and the boyfriend of Hawthorne’s mother. Millions of dollars were poured into the attempt to clone Joan Hawthorne’s dog, Missy, a husky-border collie mix.

SONY DSCWhen Texas A&M dropped the project, scientists as Seoul National University in South Korea began their own effort to clone the world’s first dog.

They picked up where American scientists left off, and dog cloning was achieved within two years with the 2005 birth of Snuppy, an Afghan hound manufactured from cells taken from a veterinary student’s dog.

Hawthorne, under the auspices of Bio Arts, later teamed up with Hwang Woo Suk, one of the lead scientists on the Snuppy project who opened his own lab after being fired from the university.

First, he had Hwang clone Missy, resulting in a dog named Mira, but when the clone was delivered to Joan Hawthorne she didn’t want her. She told a New York Times reporter at the time the puppy was too rambunctious.

SONY DSCThen Hawthorne and Hwang teamed up to produce and sell more clones. They held a “Golden Clone Giveaway,” in which a free cloning was offered to the winner of an essay contest, and an online auction where five winning bidders, offering upwards of $150,000, had their dogs cloned.

A second South Korean company RNL Bio, with help from another of Snuppy’s creators at SNU, was also cloning dogs — and it produced the first one sold to a customer not connected to the industry, a pit bull named Booger, five copies of which were cloned from the dead dog and, eventually, brought home by the California woman who owned him.

RNL pulled out of cloning pet dogs in 2011, not long after the publication of my book, “DOG, INC: The Uncanny Inside Story of Cloning Man’s Best Friend.”

Hawthorne had already stepped away from the business by then. In September of 2009, Hawthorne pulled out of the partnership with Hwang, citing, among other reasons, his concerns that accepted animal welfare protocols — or at least those accepted by most Western countries — weren’t being followed by the South Koreans.

He also, at the time, blamed court fights over patent rights, the high cost of cloning, deformities and abnormalities that occurred in the cloning process, and what he called the “distraction factor” — annoying questions from the media and bloggers about the wisdom and ethics of cloning dogs.

doginccover (5)(As a newspaper reporter who wrote one of the earliest articles on commercial dog cloning, then a blogger, and then the author of “Dog, Inc.,” an expose of the dog cloning industry, I’m pretty sure that latter group included me.)

In his interview wih the Mirror, Hawthorne referred to the vast numbers of dogs that it took — up to 80, he said — to clone just one.

And, he said, random dogs used for cloning by Korean researchers were returned to the dog farms they were borrowed from — farms where dogs are raised for their meat.

“That is why I got out,”  Hawthorne said. “I couldn’t care less if the cloning business world collapses but I care about suffering.”

Sooam told me, in 2009, that dogs used in the process were returned to the farms. In more recent years, however, Sooam has insisted that both the dogs from whom egg cells are harvested, and those who serve as surrogate mothers, are sent to adoptive homes when their use in the laboratory is completed.

Hawthorne’s remarks came after the birth of Mini Winnie, a dachshund cloned by Hwang’s lab for a London resident who won a contest sponsored by Sooam. As Sooam attempts to spread the word about its unusual service, Hawthorne has taken to speaking out against it.

SONY DSC“Dog cloning is unviable,” Hawthorne said. “It cannot be achieved at a price people can afford.”

Hawthorne now cares for two clones of Missy — Mira and Missy Too.

The Mirror reports Hawthorne has more recently been working on cures for human cancer and Alzheimer’s, and the newspaper quoted him as saying human cloning would be safer and more viable than dog cloning.

“Unlike the dog industry, no human would die.”

(Photos: Lou Hawthorne with Mira; Snuppy at Seoul National University, James Symington, winner of the “Golden Clone Giveaway,” with five clones of his former police dog, TrakR, in Los Angeles; Mira at the dog park; by John Woestendiek)

How many legs does it take to frolic?

This irrepressible boxer, known as Duncan Lou Who, took his first trip to the beach last month, where he demonstrated that having only two legs in no way limits him, or the fun that is to be had.

That’s the thing about beaches, and about dogs — the beach leads our souls to consider the possibilities; dogs show us, with persistence, we can reach them.

duncanlouwhoDuncan Lou Who, now nine months old, was born with severely deformed rear legs that had to be removed. He learned to walk with a specialized wheelchair, but didn’t think much of the device, and now no longer requires it — as you can see here.

The clip was uploaded to YouTube March 22, and it has been viewed more than 2 million times.

According to Panda Paws Rescue, a nonprofit in Vancouver, Washington, Duncan has seemed a happier little dude since he has learned to get about on his own.

Duncan is in fairly good health, but is not up for adoption. Nor is he likely to be equipped with prosthetic devices.

“He is not a candidate for prosthetics because he doesn’t have a femur to attach them to, and we will not use him for experiments to try and find something else to [sic] could do more harm than good,” Panda Paws Rescue wrote.

“He is lean, yes. He is a Boxer puppy who is missing almost a 1/4 of his body and uses twice the energy of a 4 legged dog. The rear half of his body has atrophied as well, from lack of use. He is on the best possible diet and his weight is monitored.”

You can learn more about Duncan on Panda Paws Facebook page.

Kiss, kiss; sniff, sniff; lick, lick

“First Kiss,” a video of strangers kissing, has become an Internet sensation.

Like a lot of Internet sensations, it’s kind of stupid, mostly staged, and less than fully honest.

But that hasn’t kept it from being shared by millions, and becoming — in less than a week — the subject of many video parodies, including a dog version we’ll show you in a minute.

It was just last week that “First Kiss” appeared on the Internet, showing, or so it appeared, newly introduced couples — after much foot-shuffling and awkwardness — locking lips on camera.

It garnered more than 30 million views in less than three days, and many viewers, based on comments, found it sweet and heartwarming, almost pure, in a tongue-sucking kind of way.

Director Tatia Pilieva posted the short film on YouTube on March 10, with little explanation. The post didn’t clearly point out the film was an advertisement for a clothing brand’s 2014 line, but said only: “We asked twenty strangers to kiss for the first time.”

It was a couple of days later that WREN, a Los Angeles womenswear brand, admitted on Twitter that the video was an advertisement, and most of its kissers were actors and models.

Some bloggers went so far to ask if that constituted a “hoax.” Others viewed it as a legitimate “filmvertisement,” and its makers explained they were just trying to make something artistic and interesting.

“We make these fashion films every season,” said WREN founder Melissa Coker. “I strive to make them an interesting film that exists on its own rather than something that feels like a commercial, and it seems to be touching people — not only people who are in fashion and would see this, but also random guys who aren’t connected at all.”

That apparently left some feeling a bit manipulated.

“Knowing it’s an ad is initially forgivable until you realize that the majority of the people kissing are actors and models,” commented a blogger on the website Fstoppers. “Then the veil of whimsy is gone and all that’s left is another well planned, viral advertisement and our suspension of disbelief.”

We wouldn’t go so far as to call “First Kiss” a hoax, and sneaky advertising isn’t anything new. While television, radio and newspapers are all pretty good at passing off advertising as editorial content these days, the Internet makes it simpler than ever — both to disguise advertising and get it published or broadcast for free.

The Internet can also take credit for a rebirth in parodies, many of which have been made of “First Kiss” already — some in better taste than others.

Our favorite, of course, is “First Sniff,” the doggie version, produced by another ad agency, Mother London. Even though it’s staged, its actors aren’t acting — just being their butt-sniffing selves.

Researchers unearth evidence of America’s earliest dog … and proof that it was eaten

A University of Maine graduate student says he has found a bone fragment from what he believes is the earliest domesticated dog ever found in the Americas — one that walked the continent 9,400 years ago.

And where he found it — ensconced in a dried-out sample of human waste — gives proof that eating dog was part of America’s culture, at least before America was America.

Graduate student Samuel Belknap III came across the fragment while analyzing a sample of human waste unearthed in  the 1970s. Carbon-dating placed the age of the bone at 9,400 years, and a DNA analysis confirmed it came from a dog — as opposed to a wolf, coyote or fox.

The Associated Press  reports that the fragment — which was the dark orange color characteristic of bone that has passed through the digestive track — was found in Hinds Cave in southwest Texas. 

The fragment provides the earliest evidence that dogs were eaten by humans in North America, and may have been bred as a food source, he said.

Belknap was studying the diet and nutrition of the people  in the Lower Pecos region of Texas between 1,000 and 10,000 years ago when he came across the bone.

Belknap and other researchers from the University of Maine and the University of Oklahoma’s molecular anthropology laboratories, where the DNA analysis was done, have written a paper on their findings, scheduled for publication in the American Journal of Physical Anthropology later this year.

The fragment is about six-tenths of an inch long and three- to four-tenths of an inch wide. Belknap said he and a fellow student identified the bone as a fragment from where the skull connects with the spine. He said it came from a dog that probably resembled the small short-haired dogs that were common among the Indians of the Great Plains.

Other archaeological findings have found evidence of domestic dogs in the U.S. as long as 8,000 years ago.

A 1980s study reported dog bones found at Danger Cave, Utah, were between 9,000 and 10,000 years old, but those dates were based on an analysis of the surrounding rock laters as opposed to carbon dating. In Idaho, researchers believed they’d found 11,000-year-old dog bones, but later tests showed them to be no more than 3,000 years old.

Worldwide, studies have found evidence of dogs going back 31,000 years from a site in Belgium, 26,000 years in the Czech Republic and 15,000 years in Siberia.

The earliest dogs in North America are believed to have come with the early settlers across the Bering land bridge from Asia.

Belknap said eating dogs was once common in Central America, and that some Great Plain Indian tribes ate dogs when food was scarce or for celebrations.

 “It was definitely an accepted practice among many populations,” he said.