Two University of Washington scientists think it might be possible to slow the aging process in canines and are launching a pilot study with 30 dogs to see if the drug rapamycin significantly extends their lifespans.
The researchers, using $200,000 in seed money from the University of Washington, plan to use pets, not laboratory animals, for the initial study, and recruit volunteer dogs — or at least dogs whose owners volunteer them — for larger scale studies in the future.
Daniel Promislow, an evolutionary geneticist, and Matthew Kaeberlein, a molecular biologist, say the study is aimed at determining whether rapamycin could lead to longer lives for dogs — as studies have shown is the case when it’s used on yeast, fruit flies, worms and mice.
“We’re not talking about doubling the healthy life spans of pets,” said Kaeberlein. “But at a minimum I would predict that you would get a 10 to 15 percent increase in average life span, and I think bigger effects are possible.”
In the pilot study, 30 large, middle-aged dogs will be involved — half receiving low doses of rapamycin, half receiving placebos.
The researchers say that subsequent studies will seek to enroll pet dogs from across the country.
Kaeberlein and Promislow hosted a meeting in Seattle last week where experts from across the country discussed the drug rapamycin and its possible effects on the health and longevity of dogs, the Seattle Times reported.
Currently used along with other medications to prevent rejection in organ-transplant patients, rapamycin has been called a promising anti-aging drug — though there have been no studies involving humans.
But almost 50 laboratory studies have shown that the compound can delay the onset of some diseases and degenerative processes and restore vigor to elderly animals, extending life spans by 9 to 40 percent.
Rapamycin functions, in part, by inactivating a protein that promotes cell growth. As a result, cells grow more slowly, which retards the spread of cancer.
Promislow, who has two elderly dogs of his own, noted that even if the drug doesn’t increase the life span of dogs, it could serve to keep them healthy longer. “We’re trying to understand why some dogs age better than others, and help all dogs age in a better way,” he said.
The drug has been shown to have serious side effects, including poor wound healing and an increased risk of diabetes, when used at the high doses required for organ transplant patients.
But the low doses used in anti-aging research with mice and other lab animals cause few side effects.
There have been no large-scale human trials. Studying how the drug affects dogs — who suffer many of the same old-age ailments as their masters — makes it possible to explore the possible benefits of rapamycin both more quickly and at a lesser cost.
If it does turn out to be a sort of fountain of youth — for dogs, humans, or both — the potential profits would be enormous.
“I think it’s worth a go, not just from what it can teach us about humans, but for the sake of the animals themselves,” said University of Alabama Biology Department Chairman Steven Austad, an expert in aging research who is not involved in the project. “It may not work in dogs, but if it did, boy, it’s going to be huge.”
According to the Seattle Times article, drug companies aren’t very interested in rapamycin because it’s no longer under patent.
But the researchers are hoping dog lovers, dog-food companies and some foundations might be willing to contribute to further research.
They’ve set up a website, dogagingproject.com,where people can donate and sign their dogs up to take part in the research.
“Given how I feel about my pets, I see this as a unique project where there’s a real potential for citizen science,” Kaeberlein said. “I think it would be great if pet owners who are really interested in improving the health of their animals would help fund this work.”
(Photos: UW scientists Matt Kaeberlein, with his dog Dobby, and Dan Promislow, with his dog Frisbee; by Steve Ringman / The Seattle Times)
Posted by John Woestendiek November 4th, 2014 under Muttsblog.
Tags: animals, anti aging, anti aging drug, biology, cancer, cells, citizen science, compound, Daniel Promislow, death, dog, dogs, drug, drugs, extending, fountain of youth, funding, geneticist, health, ifespan, laboratory, life, lifespans, lives, longer, Matthew Kaeberlein, molecular, pets, rapamycin, research, sickness, study, university of washington
Bentley and Nina are together again.
Dallas nurse Nina Pham reunited with her dog, Bentley, Saturday — after her successful treatment for Ebola and Bentley’s 21-day quarantine, during which the Cavalier King Charles spaniel repeatedly tested negative for the disease.
Pham was diagnosed with Ebola and hospitalized after caring for Thomas Eric Duncan — the first person to die of Ebola in the United States — at Texas Health Presbyterian Hospital in Dallas.
She was later transferred to the National Institutes of Health in Bethesda, Md., where she was declared free of the virus and released on Oct. 24.
Bentley’s quarantine ended at 2 a.m. Saturday and he was in Pham’s arms by 8:30 a.m., according to the Dallas Morning News.
“I join everyone in Dallas in welcoming Nina and Bentley back to the community,” Mayor Mike Rawlings said at a news conference at Hensley Field in southwest Dallas.
Unlike in Spain, where the first dog of an Ebola patient was exterminated, officials in Dallas showed a more compassionate response — and, given there have been no reports of dogs and cats getting sick with the disease, a more reasonable one — deciding to hold the dog in seclusion and monitor him.
During Bentley’s 21-day confinement at the decommissioned naval air base, vets wearing full protective suits brought him food and water and collected feces, urine and blood samples for tests as a lab in Dallas.
“I’d like to take a moment to thank people from all around the world who have sent their best wishes and prayers to me and Mr. Bentley,” Pham, 26, said.
“After I was diagnosed with Ebola, I didn’t know what would happen to Bentley or if he would have the virus,” she said. “I was frightened that I could possibly not know what would happen to one of my best friends.”
Pham thanked the Dallas Animal Services staff, Texas A&M University and the College of Veterinary Medicine and Biomedical Sciences, and state and county health workers.
“Thank you again for helping taking care of Bentley over the last 21 days, caring for him as if he was your own and showing America that passion and love is abundant and alive,” she said.
“I feel like Bentley reentering my life is yet another reminder of hope and encouragement for me moving forward,” she added.
Bentley will turn two later this month.
(Photo: Andy Jacobsohn / Dallas Morning News)
Posted by John Woestendiek November 2nd, 2014 under Muttsblog, videos.
Tags: animals, bentley, cavalier king charles spaniel, dallas, dallas animal services, disease, dogs, ebola, health, hospital, nina pham, nurse, pets, quarantine, reunion, virus
It may only be a short-term one, but a dying man in a Kentucky hospital seemed to have a new lease on life after a visit from his Chihuahua.
And ditto for the dog.
James Wathen, after a month in the hospital, wasn’t doing well, and had stopped eating, hospital workers say.
Social workers at Baptist Health Corbin, trying to lift his spirits, talked to him and learned he was troubled by the loss of his dog, Bubba, who had been picked up by animal control after he was hospitalized.
Between hospital staff and workers at the Knox-Whitley Animal Shelter, Bubba was tracked down at a foster home, and — despite rules forbidding dog visits — one was arranged at the hospital earlier this month, WKYT reported.
“One of our social workers realized it was mourning the loss of the dog that was making our patient even worse and emotionally unhealthy. We pulled out all the stops and found the dog,” Kimberly Probus, chief nursing officer at Baptist Health Corbin, said.
“There wasn’t a dry eye in the room,” Probus said of the reunion.
Wathen, 73, began to cry when he saw his elderly, one-eyed Chihuahua, and then his mood began to brighten.
Bubba’s condition — he’d been emotionally distraught since their separation, and had stopped eating, too — also seemed to improve.
Hospital officials say they plan to have Bubba visit Wathen regularly, and — based on what they saw — they are also looking at implementing a new pet visitation policy.
“To see James and Bubba get back together. It was heartwarming. It’s why we do what we do,” Mary-Ann Smyth, Knox-Whitley Animal Shelter President, said.
Smyth said Bubba seemed sad on the way to the hospital, but perked up about 20 steps from Wathen’s room.
“The dog quit eating a week ago, which is very strange,” she told Today. “The dog didn’t know where James was and James didn’t know where the dog was and believe it or not, they both stopped eating at about the same time.”
By the time Bubba returned for a second visit on Oct. 14, there were visible changes in both Wathen and Bubba’s conditions.
“He’s done a complete turnaround, Smyth said of Wathen. “He’s speaking, he’s sitting up, he’s eating. He doesn’t look like the same guy. And the dog is eating and doing better now, too.”
Posted by John Woestendiek October 24th, 2014 under Muttsblog, videos.
Tags: animals, baptist health corbin, bond, bubba, chihuahua, dog, dogs, health, hospital, james wathen, kentucky, knox-whitley animal shelter, loss, mourning, patient, pets, reunion, separation, shelter, visits, wellness
The Spanish nursing assistant whose dog was exterminated after she was found to have contracted Ebola from a patient has been pronounced free of the virus.
But along with the good news, Teresa Romero has learned what the rest of the world has known for two weeks.
Her dog Excalibur was seized, killed and incinerated days after she was diagnosed after officials hastily pronounced him a health risk — despite no evidence the dog had the disease, and over the objections of family members and protesters.
“She is asking herself why they killed the dog, who wasn’t to blame for anything,” Limón told EL PAIS.
Limón, staying in a room a floor below his wife at Madrid’s Carlos III Hospital, said he and his wife are pleased with her recovery, but frustrated by what happened to Excalibur, and by how Romero was criticized by health officials for not following proper hospital protocol.
“I couldn’t fight when they killed the dog and I couldn’t defend my wife when they said all those lies and slanderous things about her,” he said.
Romero tested positive Oct. 6 after coming in contact with Spain’s first Ebola patient.
As part of her treatment, she received plasma from a recovered Ebola patient, but health authorities have disclosed no more treatment details, according to NBC.
Just two days after she was diagnosed with the disease, health officials had her large mixed breed dog, Excalibur, seized, killed and incinerated out of fear he might have gotten the disease.
Meanwhile, in the U.S., Bentley, the first dog of an American Ebola patient, is being held in quarantine and tested regularly. The Cavalier King Charles spaniel shows no signs of the disease, officials say,.
Bentley is being cared for at the Hensley Field Services Center, a former military reserve base in southwest Dallas. He will continue to be tested and monitored until at least early next month.
Posted by John Woestendiek October 23rd, 2014 under Muttsblog.
Tags: animals, bentley, dog, dogs, ebola, euthanasia, excalibur, health, hospital, javier limon, madrid, pets, quarantine, spain, teresa romero, virus
You’d think in a world preparing for Ebola — especially in a country as sophisticated, dog-crazy and health-oriented as ours — someone would have given it at least a moment’s thought.
You’d think — between all the agencies and organizations, protocols and precautions; between the National Institutes for Health, the Centers for Disease Control and the American Veterinary Medical Association — someone somewhere would have stood up and said, hey, what about our dogs?
Instead, with Ebola’s spread to countries outside Africa, public health officials find themselves scratching their heads and — even though there’s no proof yet that dogs can transmit the disease — considering options as drastic as incarceration and extermination for the pets of humans diagnosed with Ebola.
Caution, of course, is good, but planning would have been better.
Excalibur was the first one to come to light. The large mixed-breed dog belonged to a nurse in Madrid who contracted the disease from Spain’s first Ebola patient. Her dog, over the family’s objections, was killed and incinerated nearly immediately upon the order of government officials.
America, or at least Dallas, took a more compassionate approach when a local nurse was determined to have contracted Ebola from a patient being treated in a hospital there. Bentley, her Cavalier King Charles spaniel, was moved into a quarantined area at a decommissioned Naval base, where he’s being tended to by hazardous material crews in full protective garb.
The question arises, and should have arisen long ago: What are we going to do with the pets of Ebola victims?
Will we turn to extermination, as the number of cases, and our fears, increase?
Will we keep them isolated in crates, bubbles or decommissioned military bases?
For how long? At what costs? Under whose supervision? And is it even necessary?
No one knows the answers to any of those questions, and the fear and uncertainty that ignorance leads to is bound to take us to some bad places, if it hasn’t already.
In an ideal world, we’d have studies to turn to — proving, one way or the other, whether dogs can contract and transmit the virus. We’d be testing them, as we do humans, before quarantining them, or at least before releasing them from that quarantine. We’d know how long, if at all, they need to be sequestered and monitored.
Instead, we’re playing a messy game of catch-up, and the argument can be made that it’s because we were wearing blinders.
Even in this supposed era of increased awareness about the health issues that cross species lines, our planet seems to once again have gotten caught up in the view that only humans matter.
Perhaps too it could be argued that, among many in America, some strange disease in Africa didn’t strike us as a big concern, or as an opportunity to learn and prepare for what might be coming. (Maybe we humans don’t like to look at the big picture when the big picture is too big, and too scary.)
What is abundantly clear is that no one, up until now, gave much thought to how Ebola might affect our dogs — if not the disease itself, at least the fear of it.
No one knows whether dogs can get the full-fledged virus. One study during the 2001-02 Ebola outbreak in Gabon showed some exposed dogs carried signs of infection, and had an immune response — but that’s not the same as getting the disease.
“Studies have shown that dogs can have an immune response to Ebola, but there have been no reports of pet dogs or cats becoming sick with Ebola or of passing the disease to other animals or people,” said Kristen Nordlund, a CDC health-communications specialist.
“In a situation where there is a dog or cat in the home of an Ebola patient, CDC recommends public-health officials evaluate the animal’s risk of exposure,” she added.
Given dogs are present in nearly half of American homes, given many of them share our beds and lick our faces, we’d like to see the CDC recommending something more than “risk evaluation.”
Between the lack of knowledge, and the lack of a clear-cut recommended response when it comes to the pets of Ebola victims, public fears will only snowball as questions go unanswered.
Why, given all our physiological similarities, can’t the dogs of Ebola patients be tested like humans are to confirm if they’ve been exposed? And if, as limited study suggests, dogs can have the virus without getting sick and dying, might there be something worth further studying in that?
“We know that you and your clients are looking for answers, and we’re working to get information for you,” the American Veterinary Medical Association says on its website.
“The AVMA is collaborating with the U.S. Centers for Disease Control and Prevention (CDC) and USDA along with other agencies and experts and is tapping into the broad expertise of our member veterinarians to develop information for our members and the public. We will strive to ensure that veterinarians have a prominent voice as these issues are discussed and decided in the U.S.”
Up until now, the CDC has taken the line that the risk of Ebola to pets is low. Its website also says there is little risk of an Ebola outbreak in the U.S.
“The risk of an Ebola outbreak affecting multiple people in the United States is very low,” says a question and answer fact sheet on the CDC website.. “Therefore, the risk to pets is also very low, as they would have to come into contact with blood and body fluids of a person with Ebola. Even in areas in Africa where Ebola is present, there have been no reports of dogs and cats becoming sick with Ebola.”
And yet Excalibur is dead and Bentley is being treated as hazardous material, and with each new case there will be new fears and ripples.
In Madrid, a dog that often played with Excalibur was surrendered to a shelter by his owners because of fears he might have contracted the disease.
Tronco was dropped off by his owners at the Spanish animal charity Escuela Canina Esga in Madrid, according to the New York Post.
“They were parents with young children and they just were not prepared to take the risk and so [they] handed him over to us,” said manager Esga Juan Esteban. “We did everything we could to reassure them that it was probably OK, but of course we couldn’t guarantee that the animal didn’t have Ebola, and so they were adamant that they didn’t want him any longer.”
The shelter, in its effort (successful) to find Tronco a new home, used only photos of him as a pup — so that, once he was adopted, he wouldn’t be recognized in public as a dog who once played with a dog whose owner has Ebola.
(Top photo: The image of Soviet Space dog Belka is from the distant past, but might we see something like it in the near future?)
Posted by John Woestendiek October 20th, 2014 under Muttsblog.
Tags: animals, answers, bentley, cross species, dallas, dallas animal services, disease, dogs, dogs and ebola, ebola, ebola dogs, euthanasia, exalibur, extermination, government, health, madrid, nina pham, officials, options, pets, planning, protocol, public health, quarantine, questions, spain, species, texas, transmit, tronco, virus, zoobiquity
As America’s first quarantined dog of an Ebola patient, Bentley’s fame may be spreading as fast as the deadly virus he may or may not have.
So much so that we suspect the Cavalier King Charles spaniel is receiving more attention, donations and expressions of support — at least online — than his sick human, Dallas nurse Nina Pham, who contracted the disease while caring for the first Ebola victim to be diagnosed in America.
This being America, a dog-crazy land, that wouldn’t be too surprising.
That funds are being raised in his name isn’t too surprising either.
That he already has a “wish list” set up on Amazon? That’s a little surprising.
As soon as Bentley was moved Monday to the undisclosed (at least initially) location he’s being quarantined and monitored in, the campaigns to raise money in his name began — ostensibly to help pay for his care, in reality for much more.
“Poor Bentley the Dog Needs You to Buy 67 Items From His Amazon Wish List,” reads the headline on a Dallas Observer blog post.
We’re sure he doesn’t truly need a $239 Lawn Boy lawnmower; or a Hamilton Beach Smooth Touch Can Opener, in black and chrome; or a thermal label printer; or a $299 microchip reader; or a Bluetooth portable GPS navigator.
But between the news media delighting in tugging our heartstrings, and some savvy sorts at Dallas Animal Services who know a fundraising opportunity when they see one, that’s the way the story is coming across.
It started where all things start, or at least end up — on Facebook.
Dallas Animal Services posted a picture (left)) wih a list of ways people could help support Bentley while he is in quarantine. The post pointed out that any extra donations — of paper towels, pee pads, toys and rawhide chews — would go to other dogs awaiting adoption.
It’s a pretty common practice among animal shelters — seizing upon the case of one sympathy-inducing dog to raise funds for more than just that one dog. It’s not an evil practice. It’s well-intentioned. While it may be a tad deceptive, it’s effective.
And given the total lack of foresight, knowledge and protocol when it comes to Ebola victims and their pets (we’ll talk more about this Monday), such fundraising techniques could prove highly necessary in the months and years ahead.
Bentley has served as a wake-up call — as, in a way, did Excalibur, the dog of Spain’s first Ebola patient. Excalibur was quickly destroyed, even though there’s no proof dogs can get Ebola or pass it on to humans.
While Dallas Animal Services is overseeing the care of Bentley — now sequestered at a decommissioned Naval air base nearby — the Dallas Fire Department’s Hazmat Response Team is doing the hands-on (and gloves on, and hazmat suits on) work, feeding and cleaning up after the dog.
Dallas Animal Services is continuing to keep the public posted on Bentley, mostly through its Facebook page, but its campaign to seek donations in his name apparently was toned down, if not halted, at least temporarily.
CBS in Dallas, which reported on the campaign, later reported that Dallas Animal Services has suspended its request for donations and pulled the Facebook post. Whether that’s because someone deemed it deceptive or exploitative isn’t known. No reason is given.
As for that Amazon “wish list,” it’s still up, but, just to be clear, those are items Dallas Animal Services need — not exclusively for the care of Bentley.
At the end of last week, a more formal funnel for donations helping the dogs of Ebola victims was set up. The city teamed up with Dallas Companion Animal Project, a nonprofit organization, which has created the Dallas Pet Emergency Transition Services fund to help pay for the care of pets affected by emergency events, including Ebola exposure.
(Photos: Dallas Animal Services)
Posted by John Woestendiek October 17th, 2014 under Muttsblog.
Tags: amazon, animal shelters, animals, cavalier king charles spaniel, dallas, dallas animal services, dog, dogs, donations, ebola, ebola dog, exposure, facebook, fundraising, health, nina pham, pet emergency transition services, pets, public, publicity, quarantine, shelters, support, transmission, wish list
Buttercup can thank dog for being alive.
The Key West cat received a blood transfusion from a dog last month — not an unknown procedure, but a pretty rare one.
It’s called xenotransfusion, and according to the U.S. National Library of Medicine only 62 cats have been known to undergo the procedure.
On Sept. 16, Dr. Sean Perry from the Marathon Veterinary Hospital pumped the blood of a greyhound into an orange tabby, in hopes of increasing the cat’s red blood cell count.
Veterinarians decided to use dog blood they had on hand after learning that suitable cat blood could take weeks to receive.
“It’s a situation where you can’t give type A blood to a type B blood cat because it’ll cause a severe immune reaction,” Perry said. “It was actually safer to give the cat dog’s blood.”
Buttercup’s owner, Ernie Saunders, brought the cat to the vet after it became lethargic, ABC reported.
After a few tests, veterinarians learned Buttercup’s red blood cell count was down to 7 percent. Cats should have a red blood cell count of at least 35 percent, Perry said.
“Cat’s blood is a little harder to come by and not as available as dog’s blood,” Perry said. “We had greyhound blood packs that we get from a blood bank that has red blood cells separated from plasma. Buttercup showed no signs of rejection during the transfusion.”
Perry said as far as veterinarians know, cats are the only animal that accept transfused blood from dogs, and that after it is done once it can’t be done again.
Since the procedure, Saunders said Buttercup has been more active.
In addition to learning about xenotransfusion, Saunders learned something else from the vet visit.
Buttercup, who he thought was a female, is a male.
Posted by John Woestendiek October 15th, 2014 under Muttsblog.
Tags: animals, blood, buttercup, cat, cat blood, dog, dog blood, florida, health, key west, marathon, medicine, pets, transfusion, veterinary, xenotransfusion