In a collaboration between Penn and the Monell Chemical Sciences Centers, Ohlin and McBain (above) and Thunder (left) will use their noses to detect the disease in humans.
Ovarian cancer kills more than 14,000 women every year and is the fifth leading cause of cancer-related deaths in women in the nation.
The collaboration, the Philadelphia Inquirer reports, takes aim at the silent killer with a combination of chemistry, nanotechnology — and dogs.
Canines have been detecting lung and breast cancer for years. With an $80,000 grant from the Kaleidoscope of Hope Foundation, the new project will assess their effectiveness in sniffing out ovarian cancer, and continue an investigation that has been underway in Sweden.
The Swedish professor behind that project, who was using his own dogs for the study, is retiring. But he’s lending his expertise to those involved in the Penn project.
“He’s been advising us along the way to we don’t repeat the same mistakes he made along the way,” said Dr. Cynthia Otto, director of the Working Dog Center and Associate Professor of Critical Care at Penn Vet.
While the disease is often difficult to diagnose, ovarian cancer’s victims have a survival rate of 90 percent. No effective screening protocol yet exists to detect cases in the early stages.
In the new program, scientists from Penn Medicine’s Division of Gynecologic Oncology will take tissue and blood samples from both healthy and ovarian cancer patients. The samples will be analyzed by chemists, scientists, computers and the puppies at the Working Dog Center, who will be exposed to healthy samples and cancer samples in vented containers they can’t access, but can smell.
The dogs began their training at 8-weeks of age.
“They’re all fabulous and they are very strong in olfaction,” Otto said.
(Photos: Philadelphia Inqurer)
Posted by John Woestendiek May 9th, 2013 under Muttsblog.
Tags: animals, cancer, cancer sniffing, chocolate labs, collaboration, detect, detecting, detection, dog, dogs, Kaleidoscope of Hope Foundation, mcbain, medicine, Monell Chemical Sciences Centers, ohlin, ovarian, ovarian cancer, penn, pets, project, research, science, sniff, sniffing, springer spaniel, study, thunder, university of pennsylvania, working dog center
It’s the one-year anniversary for 120 beagles who, around this time last year, learned the true meaning of independence.
Up until then, even here in the land of the free, they weren’t.
Instead, like thousands of other beagles bred and born for the sole purpose of laboratory use, they’d never experienced what most dogs take for granted — things like grass and dirt and running — and were destined, once their use in testing was complete, for something quite contrary to a loving home.
The beagles had been left locked in a research facility operated by Aniclin Preclinical Services in Warren County, N.J. after its parent pharmaceutical company went bankrupt. When their situation came to light, a judge order the dogs turned over to rescue groups.
One year ago, a group of them were welcomed to Pets Alive Animal Sanctuary in New York, where work began on socializing them so they could be adopted out as family pets.
This coming Sunday, some of them will gather for a reunion.
About 35 of the adopters stay in touch on Facebook, offering support and following each others progress through photos and stories.
They — and any of the others who adopted a “freegle,” as they are prone to calling the dogs rescued from the laboratory — are gathering July 10, from 12:30 to 4 p.m., at Kennedy Dells Park, 355 North Main Street in New City, New York.
Among those attending will be a beagle named Grace, who has her own Facebook page, called Saving Grace. Grace’s owner said that while word of the reunion has gotten out among those who stay in touch, other beagles adopted from the group are also invited, as well as everyone else who participated in rescuing them.
Shelters, sanctuaries, volunteers and staff are “most welcome to attend and meet the families and hear the stories of how the Freegles have been adjusting to the good life.”
(For questions or to RSVP, send an email to email@example.com.)
I met several lab beagles while researching my book — including some flourescent beagle clones in South Korea. In Texas, I interviewed the woman who cared for the beagles used in attempting to clone a dog at Texas A&M University.
Jessica Harrison, a graduate student at the time, was in charge of socializing the beagles and finding adoptive homes for them — not usually the case or fate of laboratory beagles — after their services in the lab were no longer required.
“What they teach them is to be still,” she told me. “As puppies, they teach them to just freeze when a person messes with them. We had to kindo of undo that and say, ‘No,we want you to move around and be excited.’
“We slowly exposed them to all the things they’d be exposed to in a family home — like TVs, mirrors, grass, trees, flowers, birds and bees. These dogs had never seen any of that. You put them down on the grass, and they’re like, ‘What’s this?’ It was kind of overwheliming. You get used to it, but at first it’s like, these are dogs, how can they not know these things?”
The use of dogs in laboratory research was declining, but it has jumped up in recent years, with much of the increase due to advancements in, and the promise of, gene therapy.
(Photos: Top photo from the Facebook page of Freegles Justice and Skipper; bottom photo by John Woestendiek)
Posted by John Woestendiek July 4th, 2011 under Muttsblog.
Tags: adopt, adopted, aniclin, animal sanctuary, beagles, best freinds, cloning, dog inc., dogs, experiments, flourescent, freed, freegle reunion, freegles, kennedy dells park, lab animals, lab beagles, laboratory, medical, new city, new jersey, new york, pets, pets alive, pharmaceuticals, rescue, research, reunion, sanctuary, science, shelter, warren county
The University of Utah has announced that it will no longer purchase dogs and cats from North Utah Valley Animal Shelter (NUVAS) — or any other animal shelter — for use in medical experiments.
The decision was praised by PETA, which has waged a lengthy campaign against the practice.
“PETA is thrilled for the dogs, cats and people of Utah now that the University of Utah has stopped using animal shelters as dirt-cheap sources of living lab equipment, marking the complete end of pound seizure in the state,’’ said Kathy Guillermo, PETA’s vice president for laboratory investigations.
Until last year, animal shelters in Utah were required to sell cats and dogs in their custody to the university under a practice known as pound seizure. A change in state law made it voluntary for shelters to participate. The North Utah Valley Animal Shelter, however, continued to supply animals for research in the belief that it was helping to ease human suffering and advance medical knowledge.
NUVAS sold the university about 100 dogs and cats a year, Director Tug Gettling told the Salt Lake City Tribune.
The practice, over the years, saw hundreds of former pets and strays sacrificed for purposes of medical experimentation — though not all that were used in experiments were killed. Last year, a pet owner who turned her dog, Sheena (above) over to the shelter was shocked to learn — when she called to see if she had been adopted — that the dog had been sold to the university for experimentation. Later, with help from PETA, she launched a successful campaign to get the dog back from the university and into an adoptive home.
According to the Tribune, the decades-old practice of buying animals from shelters was halted by the university in mid-January.
Thomas Parks, the university’s vice president for research, said the decision was aimed at bringing an end to the campaign against the shelter by animal welfare advocates. Parks said the university will instead obtain dogs bred for laboratory use by certified breeders — a costlier but less controversial method.
PETA’s Guillermo said she hoped the added cost of specially bred animals would lead the university to seek alternatives to using live animals in its experiments.
Parks said employees at the non-profit municipal shelter “have been suffering a lot of harassment” and that the shelter has received thousands of hostile emails and phone calls, several bomb threats and at least three public protests.
A Salt Lake Tribune investigation a year ago found that about 60 percent of all shelter animals the shelter provided to the university between 2007 and 2009 were killed after being experimented on, while the rest entered an adoption program.
Posted by John Woestendiek March 3rd, 2011 under Muttsblog.
Tags: animal welfare, animals, anti-vivisection, biomedical, campaign, cats, dogs, experimental, experiments, laboratory, labs, medical, north utah valley animal shelter, nuvas, people for the ethical treatment of animals, peta, pound seizure, practice, rescue, research, shelter, strays, university of utah, use, utah, vivisection
Seventy-five years after his death, scientists say they have determined what killed Hachiko, the legendary Akita whose story has been immortalized in his native Japan and the rest of the world.
Japan’s most famous dog — though rumors have persisted for decades that worms did him in, or that he swallowed a chicken skewer that ruptured his stomach — had heart and lung cancer, scientists now say.
Hachiko became legendary for the loyalty he showed by waiting for his owner every day at a train station — for 10 years after his master died.
Hachiko died in 1935 at the age of 13. After his death, researchers at what is now the University of Tokyo performed an autopsy on Hachiko’s body and discovered roundworms in his heart and liquid collected in his abdomen.
Using more sophisticated tests like MRI’s, the Mainichi Daily News reports, a team of scientists at the University of Tokyo team analyzed Hachiko’s preserved organs and discovered large cancers in the heart and lungs. They speculated that the cancer may have spread from the lungs to the heart. Hachiko also had filariasis (a worm-caused diseased), and it’s possible that could have caused his death as well, said professor Hiroyuki Nakayama, part of the research team.
Hachiko’s preserved organs are displayed at a University of Tokyo resource center in Bunkyo Ward, Tokyo, along with a bust of his owner. A “stuffed” Hachiko is also on display at the National Museum of Nature and Science in Tokyo’s Taito Ward. A statue of Hachiko was erected in his honor at Shibuya Station.
Hachiko accompanied his owner, a university professor named Eisaburo Uyeno, to the train station every day and watched him leave for work. Every evening the dog would be waiting for him when he returned. When Uyeno died, Hachiko continued going to the train station every day to wait for his master for about ten years.
The legend has been told in numerous forms in the 75 years since, most recently as a childrens’ book and a 2009 movie remake, re-set in Rhode Island, starring Richard Gere.
Posted by John Woestendiek March 2nd, 2011 under Muttsblog.
Tags: akita, animals, cancer, cause of death, death, dog, dogs, eisaburo, hachiko, heart cancer, japan, japanese, legends, loyalty, lung cancer, medical, news, pets, professor, research, roundworms, science, shibuya, tests, train station, ueno, university of tokyo, uyeno, veterinary
One year after he was rescued from an ice floe, Baltic remains on the high seas — just not in them.
The crew of a Polish ship, named Baltica, pulled the dog from the icy waters of the Baltic Sea after observing him struggling. The dog was first seen on an ice floe in the Vistula River. Some estimated at the time that he traveled 70 miles atop the floe on the river, then another 20 miles out to sea.
Several people came forward wanting to adopt Baltic after his story gained headlines around Europe, but his rescuer Adam Buczynski decided to keep him.
Despite his bad experience, the dog is now there regularly at sea, serving as the research ship’s pet and mascot. He shows signs of anxiety when the sea is rough but sails around happily with the crew when it is calm, Buczynski said.
Posted by John Woestendiek February 1st, 2011 under Muttsblog.
Tags: adam buczynski, animals, baltic, baltic sea, baltica, dog, dogs, floe, headlines, ice, mascot, news, one year later, pets, poland, polish, rescued, research, saved, sea, ship, update, video, vistula river
He further advises that anyone who is licked by a dog wash the area immediately.
To me, a guy who has spent the last eight months with my dog nearly constantly at my side during our travels across America — including in whatever bed we happen to be sleeping in at night — that seems a massive over-reaction.
Bruno Chomel, a professor at the School of Veterinary Medicine at the University of California, Davis, says that, while such cases aren’t common, people have contracted infections from sleeping with, kissing and being licked by their pets. Chomel and fellow researcher Ben Sun, of the California Department of Public Health, express their views in the latest issue of the journal Emerging Infectious Diseases.
I don’t subscribe to that publication, because my theory is the surest way to get a disease is not from sleeping with your dog, but from reading about that disease.
Though I sleep with my dog nightly, I’m not so much concerned about Zoonoses, or diseases transmitted to humans by animals, as I am about Merckitis, a chronic case of which I’ve suffered from since childhood.
It stemmed from a big blue book called The Merck Manual, on my mother’s bookshelf, which allowed you to, based on your symptoms, diagnose your medical issue, read about the treatment and determine, in my case, if I was going to live to see 13.
I must have diagnosed myself with a dozen different diseases, many of them fatal, in the course of matching up my symptoms — usually those of a common cold — with the worst possible maladies.
I remember one night that — congested, unable to breathe through my nose and worried that my throat breathing pipe (non-medical term) might close up – I gathered the necessary supplies to perform an emergency tracheotomy (bic pen, with the ink part removed, pocket knife, duck tape) and kept them under my bed, alongside the book.
The Internet has made it much easier to wrongly self diagnose — just a few clicks and you can jump to the conclusion that you have the most dreaded disease imaginable. The key word there being imaginable. In a way, those medical self-help websites, rather than lessen the need for doctors, only create more of one as we, fueled by our fears, rush to confirm our faulty self diagnoses.
Pulled muscle? I was sure it was a heart attack.
Of course, such concerns are not always entirely baseless, and many of them should be checked out by professionals. But often, they’re only in our heads — having been placed there by WebMD, yourdiagnosis.com, familydoctor.org and the like. Often they are really far-fetched, instilling a fear out of all proportion with reality, which is the case with Chomel’s study, or at least his remarks:
“I think pets can be very nice in the home environment, but certainly, they don’t belong on the bed,” Chomel told LiveScience.
Chomel says humans can contract bubonic plague from flea-infested pets, bacterial infections resistant to multiple strains of antibiotics, and various parasitic worms.
Since 1974, Chomel says, multiple cases of plague have been associated with people in the southwestern U.S. who allowed flea-infested cats to sleep with them. And in a 2008 outbreak, a study found that people infected with bubonic plague were “more likely to have shared a bed with a dog than uninfected counterparts.” (Despite that, I still don’t recommend sharing a bed with uninfected counterparts.)
The authors cite surveys conducted in the U.S., the United Kingdom, France and the Netherlands that show up to 45 percent of dogs sleep in their owners’ bed.
Several reports of bacterial infections have been attributed to sharing a bed with pets, and in “multiple” cases, they report, patients acquired various infections after allowing their dogs or cats to lick wounds or damaged skin.
That’s the total opposite of my philosophy. Whenever I get a boo-boo, the first thing I do is let Ace lick it. Then it feels better. If thousands of microscopic parasites enter my bloodstream by doing so, so be it … join the party, fellas.
Don’t tell me not to sleep with my dog, especially when it’s this cold. That’s like saying, because there may be some impurities in the air, I should stop breathing. I’m going to continue to engage in both risky behaviors.
And if worse comes to worst I can always, after consulting my Merck Manual, perform an emergency tracheotomy.
OUR FAVORITE READER COMMENT: “Pity poor Chomel. He has obviously not enjoyed the delight of a canine companion…I’ve spent the past 50 years sleeping with dogs – most of the canine persuasion – and if anything it must have strengthened my immune system … The plague? Only a plague of comfort and love. Poor Chomel.”
(For all the comments on this post, click the comment button below, and scroll to the bottom to leave one of your own.)
Posted by John Woestendiek January 24th, 2011 under Muttsblog.
Tags: animals, bruno chomel, bubonic, davis, diagnosis, disease, dog, dogs, emergency, fleas, germs, infection, infectious, kisses, licks, medical, parasites, pets, plague, research, science, self diagnosis, self help, sick, sleeping with dogs, tracheotomy, transmit, transmitted, university of california, veterinary, zoonoses, zoonosis
A University of Maine graduate student says he has found a bone fragment from what he believes is the earliest domesticated dog ever found in the Americas — one that walked the continent 9,400 years ago.
And where he found it — ensconced in a dried-out sample of human waste — gives proof that eating dog was part of America’s culture, at least before America was America.
Graduate student Samuel Belknap III came across the fragment while analyzing a sample of human waste unearthed in the 1970s. Carbon-dating placed the age of the bone at 9,400 years, and a DNA analysis confirmed it came from a dog — as opposed to a wolf, coyote or fox.
The Associated Press reports that the fragment — which was the dark orange color characteristic of bone that has passed through the digestive track — was found in Hinds Cave in southwest Texas.
The fragment provides the earliest evidence that dogs were eaten by humans in North America, and may have been bred as a food source, he said.
Belknap was studying the diet and nutrition of the people in the Lower Pecos region of Texas between 1,000 and 10,000 years ago when he came across the bone.
Belknap and other researchers from the University of Maine and the University of Oklahoma’s molecular anthropology laboratories, where the DNA analysis was done, have written a paper on their findings, scheduled for publication in the American Journal of Physical Anthropology later this year.
The fragment is about six-tenths of an inch long and three- to four-tenths of an inch wide. Belknap said he and a fellow student identified the bone as a fragment from where the skull connects with the spine. He said it came from a dog that probably resembled the small short-haired dogs that were common among the Indians of the Great Plains.
Other archaeological findings have found evidence of domestic dogs in the U.S. as long as 8,000 years ago.
A 1980s study reported dog bones found at Danger Cave, Utah, were between 9,000 and 10,000 years old, but those dates were based on an analysis of the surrounding rock laters as opposed to carbon dating. In Idaho, researchers believed they’d found 11,000-year-old dog bones, but later tests showed them to be no more than 3,000 years old.
Worldwide, studies have found evidence of dogs going back 31,000 years from a site in Belgium, 26,000 years in the Czech Republic and 15,000 years in Siberia.
The earliest dogs in North America are believed to have come with the early settlers across the Bering land bridge from Asia.
Belknap said eating dogs was once common in Central America, and that some Great Plain Indian tribes ate dogs when food was scarce or for celebrations.
”It was definitely an accepted practice among many populations,” he said.
Posted by John Woestendiek January 19th, 2011 under Muttsblog.
Tags: america, analysis, anthropology, archaeology, ate, bone, carbon dating, diet, digested, dna, dog, domesticated, earliest, eaten, evidence, excrement, first, fragment, hinds cave, human, indians, nutrition, oldest, research, samuel belknap, study, texas, university of maine, waste