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Tag: snuppy

South Korean university announces that Snuppy has been recloned

reclonedsnuppy

The world’s first canine clone — an Afghan hound named Snuppy who died in 2015 — has been recloned, scientists at Seoul National University in Korea have announced.

It’s no big surprise, and it’s no huge achievement, but the scientists say they created the three clones of Snuppy to “immortalize” the “milestone” Snuppy represented — and that the clones will allow them to further study the lifespan of cloned dogs.

Snuppy, who spent most of his life in a laboratory, died at age 10 in April 2015.

“Three healthy reclones of Snuppy are alive, and as with Snuppy we do not anticipate that the reclones will go through an accelerated rate of aging or will be more prone to develop diseases than naturally bred animals,” the team wrote in Scientific Reports, a journal from the publishers of Nature.

To create the new clones, the scientists used fat-derived stem cells taken from Snuppy when he was five years old.

The stem cells were taken from his belly fat and frozen. Years later, they were thawed, grown in culture and then injected into enucleated eggs taken from female donors. The reconstituted eggs were then zapped with an electrical shock to fuse the membranes of the egg and stem cells. Ninety-four of them were transferred to surrogate female dogs.

Four resulted in births, but one of the pups died four days after it was born from severe diarrhea, the scientists reported.

The three remaining dogs will also live their lives in the lab, being monitored and undergoing tests the scientist say they suspect will dispel the notion that cloned animals die early deaths.

They say the second generation of Snuppy clones will contribute to a “new era” in the study of the health and longevity of cloned animals, and that they might contribute to cures being found for human diseases.

But with dog cloning having become big business — and having been initially researched with profits in mind — it’s no surprise that the latest research, funded in part by the Korean government, aims to dispel the thinking that clones live abbreviated lives.

Snuppy’s birth came eight years after Dolly the sheep became the first cloned mammal in 1997. Dolly died prematurely, at age six.

Snuppy

Snuppy

When Snuppy was born in 2005, Time magazine named him one of the most amazing inventions of the year. What wasn’t reported much, at least not initially, were the intrusive procedures involved, the birth defects that resulted, the surplus dogs that resulted, and the long list of animal welfare concerns about the process.

In the article written in Scientific Reports, by the researchers involved, those concerns also get short shrift.

“Animal cloning has gained popularity as a method to produce genetically identical animals or superior animals for research or industrial uses,” they write.

“There is lots of pet cloning going on right now. Owners are concerned whether their clones will live (a normal lifespan) or if they will experience accelerated aging and die early. So, there is some business concern,” said said co-author of the study CheMyong Jay Ko, of the University of Illinois.

The clones of Snuppy might also provide insights into the development of cancer and other diseases, Ko said.

(Top photo from the National Post; bottom of photo by John Woestendiek)

To read more about the birth of dog cloning and how it became a big business, read John Woestendiek’s book, “Dog, Inc.

Chinese lab produces what it says is the world’s first “superdog” clone

longlong4

Chinese scientists say they have produced a “superdog” clone — and that the technology will enable them to mass produce dogs that are extra strong and extra fast.

And, unless you are a fan of the doggy version of eugenics, you might find that extra scary.

The beagle, named Long Long, was born in May, becoming one of China’s first canine clones and, the scientist’s maintain, the world’s first genetically modified canine clone.

“This is a breakthrough, marking China as only the second country in the world to independently master dog-somatic clone technology, after South Korea,” said Lai Liangxue, a researcher of Guangzhou Institute of Biological Medicine and Health with the Chinese Academy of Science.

The beagle puppy was genetically engineered by deleting a gene called myostatin, giving him double the muscle mass of a normal beagle.

longlongHe was one of 27 puppies created at Sino Gene, a biotech company based in Beijing — all clones of a laboratory research dog named Apple, according to published reports.

The researchers created 65 embryos through cloning, and genetically modified all of them.

Only Long Long had his myostatin deleted.

By combining genetic editing and cloning, scientists say they can produce “superbreeds” that are stronger and faster.

“With this technology, by selecting a certain gene of the dog, we can breed an animal with more muscles, better sense of smell and stronger running ability, which is good for hunting and police applications,” Lai said.

He also suggested that the gene-editing technology could be commercialized and further applied to create dogs with diseases such as autism, Parkinson’s and diabetes, for use in medical research.

It’s just the latest chapter in dog cloning, which has a frightening history and, potentially, an even scarier future.

Efforts to clone dog began in the U.S., with early research at Texas A&M funded by backers who saw cloning people’s pets — often sick, dying or even dead — as a profitable business enterprise.

Canine cloning wasn’t achieved until a few years later at Seoul National University in South Korea when Snuppy, the world’s first canine clone, was born in 2005.

The service would be offered to pet owners by several businesses, only one of which remains, Sooam Bioengineering Research Institute, the laboratory of controversial South Korean scientist Hwang Woo Suk.

longlong2Twelve years would pass before China became the second country to clone dogs — and clone them with a twist.

Lai says his team will be able to “batch produce” customized dogs through cloning and gene-editing, which in addition to possible military and law enforcement uses, would create an endless supply of dogs for use in laboratories by medical researchers.

The researcher has worked for years on genetically modifying dogs. By mastering cloning, and combining it with his gene-editing, he’s able to endlessly duplicate any successes he achieves.

As with Dolly the sheep and Snuppy the dog, Lai’s achievement is seen as ominous by some.

“It’s true that the more and more animals that are genetically engineered using these techniques brings us closer to the possibility of genetic engineering of humans,” David King, director of Human Genetics Alert, told the Express..

“That does set us on the road to eugenics,” King added. “I am very concerned with what I’m seeing.”

Me, too. Dog cloning raises some significant animal welfare concerns. Technology, especially when coupled with greed or ego, tends to run amok. Eugenics is a nightmarish pursuit, as is its canine version. Creating diseased dogs for medical research is just plain wrong.

On top of all that, this latest twist being touted by the Chinese researchers fails to recognize one simple fact:

Dogs are already super.

(Photos: Sino Gene)

Dog clones: Now made in America

nubia2

Just as the earliest efforts to clone a dog in America didn’t make a huge splash, news-wise, neither did the recent birth — nearly 20 years later — of the first made-in-America canine clone.

ViaGen, a genetic preservation company in Texas, announced at the end of July that the first successful cloning of a dog in America had led to a birth, and that the Jack Russell terrier pup had been delivered to clients.

Chances are you haven’t read about it — because hardly anyone has written about it.

Including me — the guy who wrote that dog cloning book.

I received an email Monday containing the press release announcing the successful cloning. It came from Andrew Lavin, a public relations consultant in New York who handles publicity for ViaGen. It was dated Sept. 12 and included the photos of the clone, named Nubia, that you see here.

When I checked online to see what news coverage the announcement had received, I found almost none — only an “article” in Pet Age magazine (actually a verbatim reprint of the company press release) in July.

When I called ViaGen’s Austin offices to clear up some of my confusion I was told the press release had originally been issued at the end of July, and they didn’t know why the one I received had been re-dated to Sept. 12.

When I asked why the announcement had not received greater news coverage, the person on the phone said only, “It was a soft press release.” She didn’t explain what that meant.

(I can only guess it means a press release sent to a limited few, vague and fuzzy on the details, and accompanied by a “we’re not going to answer any questions” attitude — one that is low-profile enough to not arouse any detractors, such as the many animal welfare organizations that frown on cloning pets, saying it is cruel to animals and exploits bereaved pet owners.)

When I asked ViaGen for more information about the cloning, I was told, “all media requests go through Andy,” meaning Andrew Lavin.

He eventually returned my call and answered my email, explaining that he had “updated” the original press release — and therefore changed the date on it.

He did seek answers to my questions and sent me ViaGen CEO Blake Russell’s responses to them. Russell sidestepped far more than he answered.

nubia1The owners of the clone are not being identified — apparently not even the state or country where they reside.

Their original dog is deceased, but they were able to have her cloned with tissue samples taken by her vet when she was spayed.

Asked where the other dogs that are needed to produce a successful clone came from — dogs in heat from whom egg cells are harvested, and female dogs who serve as surrogates — Russell said ViaGen Pets purchases oocytes from an unnamed provider and that “ViaGen Pets uses a production partner to supply the needed surrogates.”

Presumably, the merging of egg and donor cells and the surgeries necessary were performed at ViaGen labs in Texas.

Texas, by the way, is where the whole crazy idea got started — though it wasn’t pulled off until scientists in South Korea cloned the world’s first dog.

Here’s the condensed version:

Shortly after the birth of the world’s first cloned mammal, Dolly the sheep, in 1996, the wealthy founder of the University of Phoenix, John Sperling, decided that cloning his girlfriend’s dog, Missy, would make for a lovely gift.

He teamed up with his girlfriend’s son, Lou Hawthorne, to find a learning institution that would be interested in cloning the world’s first dog.

They chose Texas A&M University and funneled millions into the project.

For years, from 1998 to 2002, researchers there tried to clone a dog. They were able to clone the world’s first pig, cat, bull and goat, but dogs, they found, were extra difficult.

Hawthorne had high hopes of turning the cloning of pet dogs into a big business, and it was during this time that he launched Genetic Savings & Clone, a company that, like Viagen, stored the cells of pets whose owners thought they might someday want a clone.

Snuppy

Snuppy

The research project at Texas A&M, eventually, was dropped, but the quest was picked up by Seoul National University in South Korea, which produced the first dog clone, Snuppy, in 2005.

The thousands produced since then — most often for bereaved pet owners seeking a duplicate of the dog they lost — have all been made in South Korean laboratories.

At one point, two Korean companies were producing dog clones for customers, and one American company was selling dog cloning, too.

Bio Arts, a company Hawthorne started in hopes of cloning dogs on its own, ended up teaming up with one of the Korean companies, Sooam, led by former Seoul National University scientist Hwang Woo Suk, to provide clones to American customers.

Among the first of those shipped back to the U.S. was a clone of Missy, which he presented to his mother, Sperling’s girlfriend.

She noted the puppy was ill-behaved, and said she didn’t want it.

SONY DSC

Surgery at Sooam

Hawthorne later pulled out of the partnership with Sooam, citing, among other reasons, his concerns that accepted animal welfare protocols — or at least those accepted by most Western countries — weren’t being followed by the South Koreans.

“A cloned dog contributes to the happiness of a family but I do not think it is possible to do it without a huge amount of suffering to hundreds of others,” Hawthorne told The Mirror, which was reporting on the first dog cloning for a customer in the UK.

In an interview with the Mirror, Hawthorne referred to the vast numbers of dogs that it took — up to 80, he said — to clone just one. And he confirmed that, as my book reported, Korean cloning researchers borrowed dogs from dog farms — farms where dogs are raised for their meat — for the process.

Today, only one of the Korean companies is still in operation.

https://www.amazon.com/Dog-Inc-Uncanny-Inside-Cloning/dp/1583333916Another Korean company that paved the way for cloning pet dogs — and provided the first clones to an American customer — pulled out of cloning pet dogs in 2011, not long after the publication of my book, “DOG, INC: The Uncanny Inside Story of Cloning Man’s Best Friend.”

ViaGen’s successful cloning of a dog lessens the likelihood of dog cloning fading away; instead it brings the process to American shores, and offers it at a much reduced price — $50,000 instead of the initial $150,000 the Korean companies charged.

ViaGen Pets says it is now the only American company offering pet cloning services — and says they are doing so “in full compliance with all U.S. regulatory standards and humane pet care practices.”

The are no federal laws against cloning dogs, or for that matter, humans, in the United States.

ViaGen,a long-time cloner of livestock, produced its first cloned cats for customers last year and it has been banking the cells of pets for more than a decade.

The company says the birth of Nubia will likely increase demand for cloning and genetic preservation of companion pet DNA.

screencapture-viagenpets-1473861354711

President Blake Russell said the company has already genetically preserved almost 1,000 pets and that there is a waiting list for the cloning procedure.

“The potential to have an identical twin to something that was very important and special in your life is an unprecedented opportunity and has brought a lot of joy to pet owners,” Russell says in the press release.

In addition to the cost of cloning, ViaGen charges a $1,600 fee and $150 a year to store tissue samples from pets whose owners may someday want to clone them.

The cloning procedure involves injecting cells harvested from the original dog into egg cells harvested from female dogs, a jolt of electricity to help them merge, and implanting the resulting embryo into a surrogate mother dog who carries the pup to birth.

ViaGen says a cloned puppy or kitten is “simply a genetic twin born at a later date, and should share many of the original’s attributes, including intelligence, temperament and appearance.”

The South Korean company guarantees only that the appearance will be identical, or nearly identical — but they often achieve that by producing multiple clones.

Many of dog cloning’s customers have come from the U.S. and the U.K. — and up to now they have been turning to Sooam Biotech to clone their dogs.

Most animal welfare organizations oppose the practice, pointing to the number of other dogs it takes to produce a clone, the intrusive procedures, the creation of surplus clones, and the sometimes nightmarish results. They also say pet cloning companies are exploiting the grief of bereaved pet owners.

There has been little outcry from them about the fact that dog cloning is now being done in America. Then again, it’s a development of which many people — possibly having missed that “soft” press release — aren’t aware.

In any case, it appears an American-born idea has finally — for better or worse — come to fruition in America.

(Photos of Nubia courtesy of ViaGen Pets; photos of Snuppy and a cloning underway at Sooam by John Woestendiek)

Second thoughts about dog cloning

SONY DSCOne of the men behind the push to clone dogs — and market the service to bereaved pet owners — seems more convinced than ever that doing so was, if not a mistake, at least a quest that led to some bad places.

Lou Hawthorne, who established a cell bank (Genetic Savings & Clone) and pushed researchers at Texas A&M University to try and clone the world’s first dog in the late 1990s — in hopes of turning dog cloning into a profitable business — said in an interview last week that cloning has led to thousands of dogs suffering each year.

“A cloned dog contributes to the happiness of a family but I do not think it is possible to do it without a huge amount of suffering to hundreds of others,” Hawthorne told The Mirror, which was reporting on the first dog cloning for a customer in the UK.

Hawthorne has been out of the dog cloning business since shutting down BioArts, the successor to Genetic Savings & Clone, which closed not long after efforts to clone a dog at Texas A&M were dropped.

That research was funded by John Sperling, the wealthy founder of the University of Phoenix and the boyfriend of Hawthorne’s mother. Millions of dollars were poured into the attempt to clone Joan Hawthorne’s dog, Missy, a husky-border collie mix.

SONY DSCWhen Texas A&M dropped the project, scientists as Seoul National University in South Korea began their own effort to clone the world’s first dog.

They picked up where American scientists left off, and dog cloning was achieved within two years with the 2005 birth of Snuppy, an Afghan hound manufactured from cells taken from a veterinary student’s dog.

Hawthorne, under the auspices of Bio Arts, later teamed up with Hwang Woo Suk, one of the lead scientists on the Snuppy project who opened his own lab after being fired from the university.

First, he had Hwang clone Missy, resulting in a dog named Mira, but when the clone was delivered to Joan Hawthorne she didn’t want her. She told a New York Times reporter at the time the puppy was too rambunctious.

SONY DSCThen Hawthorne and Hwang teamed up to produce and sell more clones. They held a “Golden Clone Giveaway,” in which a free cloning was offered to the winner of an essay contest, and an online auction where five winning bidders, offering upwards of $150,000, had their dogs cloned.

A second South Korean company RNL Bio, with help from another of Snuppy’s creators at SNU, was also cloning dogs — and it produced the first one sold to a customer not connected to the industry, a pit bull named Booger, five copies of which were cloned from the dead dog and, eventually, brought home by the California woman who owned him.

RNL pulled out of cloning pet dogs in 2011, not long after the publication of my book, “DOG, INC: The Uncanny Inside Story of Cloning Man’s Best Friend.”

Hawthorne had already stepped away from the business by then. In September of 2009, Hawthorne pulled out of the partnership with Hwang, citing, among other reasons, his concerns that accepted animal welfare protocols — or at least those accepted by most Western countries — weren’t being followed by the South Koreans.

He also, at the time, blamed court fights over patent rights, the high cost of cloning, deformities and abnormalities that occurred in the cloning process, and what he called the “distraction factor” — annoying questions from the media and bloggers about the wisdom and ethics of cloning dogs.

doginccover (5)(As a newspaper reporter who wrote one of the earliest articles on commercial dog cloning, then a blogger, and then the author of “Dog, Inc.,” an expose of the dog cloning industry, I’m pretty sure that latter group included me.)

In his interview wih the Mirror, Hawthorne referred to the vast numbers of dogs that it took — up to 80, he said — to clone just one.

And, he said, random dogs used for cloning by Korean researchers were returned to the dog farms they were borrowed from — farms where dogs are raised for their meat.

“That is why I got out,”  Hawthorne said. “I couldn’t care less if the cloning business world collapses but I care about suffering.”

Sooam told me, in 2009, that dogs used in the process were returned to the farms. In more recent years, however, Sooam has insisted that both the dogs from whom egg cells are harvested, and those who serve as surrogate mothers, are sent to adoptive homes when their use in the laboratory is completed.

Hawthorne’s remarks came after the birth of Mini Winnie, a dachshund cloned by Hwang’s lab for a London resident who won a contest sponsored by Sooam. As Sooam attempts to spread the word about its unusual service, Hawthorne has taken to speaking out against it.

SONY DSC“Dog cloning is unviable,” Hawthorne said. “It cannot be achieved at a price people can afford.”

Hawthorne now cares for two clones of Missy — Mira and Missy Too.

The Mirror reports Hawthorne has more recently been working on cures for human cancer and Alzheimer’s, and the newspaper quoted him as saying human cloning would be safer and more viable than dog cloning.

“Unlike the dog industry, no human would die.”

(Photos: Lou Hawthorne with Mira; Snuppy at Seoul National University, James Symington, winner of the “Golden Clone Giveaway,” with five clones of his former police dog, TrakR, in Los Angeles; Mira at the dog park; by John Woestendiek)

UK’s first canine clone is born in Seoul

miniwinnie

With more than 500 canine clones now roaming the world, you wouldn’t think the fact that one has been produced for a pet owner in the UK would make such a big splash.

But it has, and a big splash is just what the cloners had in mind.

To introduce its unique service to Britain, Sooam Biotech, the South Korean laboratory that’s now the only company cloning dogs, borrowed from an earlier chapter in dog cloning’s bizarre history. It held a public contest, awarding a free cloning as the grand prize.

The winner: Rebecca Smith, 29, of London, who learned in late March that a clone of her 12-year-old dachshund Winnie had been born in a Seoul laboratory, BBC reported.

She named the dog Mini Winnie.

The competition saw dog owners submit videos of their dogs and compete for the chance to “immortalize” their pet for free. The bill for dog cloning normally runs around $100,000.

“Sooam Biotech is looking for one person with the most special and inspiring reason for cloning his/her beloved dog,” the company said in announcing the contest.

The contest was similar to one held in the U.S. when dog cloning first hit the market. It was called the “Golden Clone Giveaway,” and the winner was TrakR, a search and rescue dog whose owner said the German shepherd found the last survivor in the rubble of 9/11.

The weird and wacky story of how dog cloning was achieved, how it was marketed, and the first customers to sign up for it can be found in my book, “DOG, INC.: The Uncanny Inside Story of Cloning Man’s Best Friend.”

The UK’s first canine clone — who won’t arrive in the country until after a 6-month quarantine period — was cloned at Sooam Biotech, a laboratory run by Hwang Woo Suk, who was a member of the Seoul National University team that produced the world’s first canine clone, Snuppy, in 2005.

That research began after an earlier effort to clone a dog in the U.S., at Texas A&M University, was unsuccessful.

The Texas A&M research was funded by John Sperling, founder of the University of Phoenix. After cloning a cat, and assorted farm animals, the Texas A&M efforts to clone a dog were called off, but Sperling’s front man, who had established a company to store the cells of dead and dying dogs (Genetic Savings & Clone), even before dog cloning was achieved, later teamed up Hwang and Sooam to offer an online auction, with the highest bidders receiving clones of their dogs.

SONY DSCHwang founded his lab after getting fired from Seoul National University when his claim to have produced the world’s first cloned human embryos was deemed fraudulent. He was later convicted of embezzling research funds and illegally buying human eggs, but his 18-month sentence was suspended.

Hwang has more recently has embarked on trying to clone a woolly mammoth from 10,00-year-old remains found frozen in Siberia.

Meanwhile, he’s churning out laboratory-created dogs, more than 500 of which have been born to surrogate mother dogs at his lab and kennel.

To create Mini Winnie, a piece of skin was taken from Winnie and transported to Seoul. Cells from the sample were placed inside an anonymous donor dog’s egg cell and, with a jolt of electricity, they merged.

Then the embryo was implanted inside a surrogate dog that gave birth, via Caesarean, to Winnie on March 30.

“The world would be a better place with more Winnies in it,” Smith, 29, says in a Channel 4 documentary, “The £60,000 Puppy: Cloning Man’s Best Friend.”

smithandwinnieSmith received the original Winnie as a present on her 18th birthday, and she says the dog helped her overcome “lots of demons,” including an eating disorder. Smith says Mini Winnie looks identical to the original, who is old and arthritic, but still alive.

Hundreds of pet owners have had dogs cloned since the first customer, a California woman who received five copies of her dead pit bull, Booger.

Critics of the process say cloning doesn’t result in the resurrection of an animal, but a laboratory-made twin, whose creation requires the involvement of numerous other dogs, and who might not act like the original at all.

Initially, two South Korean companies were cloning dogs for pet owners (and even more for research purposes), but one of the, RNL Bio, has pulled out of the dog-cloning business.

While the cloning process has grown more efficient, some animal welfare groups say risks are still high.

Dr Katy Taylor, Head of Science at The British Union for the Abolition of Vivisection, said: “Cloning is a very unpredictable and extremely wasteful process … In order to produce just one ‘perfect’ clone, many puppies with the same genes as a loved animal will be born … Some of these puppies will be aborted or will die soon after birth from unpredictable health complications and severe birth defects.”

Defective pups, and the South Korean laboratory’s failure to follow animal welfare protocols, were among the reasons cited by the American company that teamed up with Hwang for pulling out of its dog cloning arrangement.

The documentary, while it mostly follows the judges as they visit with contestants and their dogs, does go some interesting places, including Edinburg, for an interview with Sir Ian Wilmut, cloner of Dolly the sheep. Wilmut doesn’t endorse pet cloning, and says he remains skeptical of it, saying it will lead to lots of disappointed customers who, despite their hopes, won’t get an animal with the same personality as the original.

There’s also an interview with a pet owner, not a contestant, who views dog cloning as a Hitleresque pursuit, and there are several allusions to the fact that some Koreans eat dog meat.

“The £60,000 Puppy: Cloning Man’s Best Friend” was made by the same independent production company that produced “I Cloned My Pet,” several episodes of which appeared on TLC.

“The £60,000 Puppy” is an improvement over those productions, which brushed aside most ethical questions and animal welfare concerns about pet cloning. While the new documentary doesn’t delve too deeply into them either, it does present something more than a one-sided view.

Like the earlier documentaries, it reinforces that most customers of dog cloning are, shall we say, eccentric sorts, and that their attachment to their dogs — as with all of us — is a powerful one.

Perhaps the most telling moment, though, comes as the judges debate — American Idol style — the public relations benefits of each contestant.

After that, the winner is … after a long, long pause … announced.

Cloning, it seems, is no longer some futuristic pipedream. It has become a reality, and apparently an entertainment form.

My view? Cloning is no game show, or at least it shouldn’t be.

(Photos: Top, Mini Winnie / Channel 4; middle, Hwang in his lab / John Woestendiek; bottom; Smith and the original Winnie / Channel 4)

My dog Ace at “My Dog Tulip”

Ace and I will be appearing at the Aperture Cinema in Winston-Salem this week for a group discussion following the showing of the animated movie, “My Dog Tulip,” based on J.R. Ackerley’s memoir of his relationship with his dog.

I’ll also be talking about, selling and signing my new book, “DOG, INC.: The Uncanny Inside Story of Cloning Man’s Best Friend.”

If you’re wondering what the human-dog bond, or a memoir about that, have in common with cloning, the answer is:

Everything.

For, in addition to the profits foreseen by entrepreneurs, it was that bond — tighter-than-ever as the 21st Century arrived–  that sparked the attempt to clone dogs, prompted customers to sign up for it and led to the emergence of a fledgling, and highly questionable, pet cloning industry.

And what, after all, is a dog clone but a living, breathing, laboratory re-creation of the past — a memoir you can pet?

The first dog whose cloning was attempted by U.S. scientists, in fact, was a border collie mix who belonged to — you guessed it — a memoir writer. Missy, as it turned out, wasn’t the first dog cloned. South Korean scientists accomplished that first with an Afghan hound, whose clone would be named Snuppy. But Missy was eventually cloned — more than five times.

Cloning wasn’t available in J.R. Ackerley’s day (the British writer died in 1967), but given the love he expressed for his German shepherd, given his many unsuccesful attempts to breed her to another purebred “Alsatian,” given the void she filled in his life and the one her passing left in it, he might have considered it, if it had been.

“Tulip,” whose real name was Queenie — publishers opted to change it, fearing its gay connotations might be too titillating for stuffy old 1950’s England — spent 14 years with Ackerley, and according to some accounts he never quite got over her death. 

“She offered me what I had never found in my life with humans: constant, single-hearted, incorruptible, uncritical devotion, which it is in the nature of dogs to offer,” he says in the book, written while she was still alive.

The movie — though, like the book, it doesn’t shy away from dogs’ bodily functions — is charming and charmingly animated, drawn and directed by Paul and Sandra Fierlinger, and narrated by Christopher Plummer, in the role of Ackerley. It also features the voices of Isabella Rossellini and Lynn Redgrave.

It tells the story of a man who, having all but given up on finding an “ideal friend” in the human world, finds one in a canine — the first dog he’s had in his life.

I’ll be leaving my ideal friend home tonight, but Ace, if he feels up to it, is scheduled to join me at the theater Wednesday night.

The movie starts at 8 p.m., both nights, with the discussion following. The Aperture Cinema is at 311 W. 4th St. in downtown Winston-Salem.

Just in time for Christmas … well, almost

I’ve written my name in books before — but always as a reminder to other people to keep their grubby paws off of them, or at least return them when they’re done.

But yesterday was a first: I signed my own book — own, as in the one I wrote.

I don’t get mail delivery here in Petite Acres, the trailer park in Cave Creek, Arizona, where Ace and I are spending December before heading back east in the last leg of our seven months of travels.

So when my publisher called to find out where to send the author’s copies of “DOG, INC.: The Uncanny Inside Story of Cloning Man’s Best Friend,” I used my brother’s address, and he delivered them over the weekend.

I won’t compare the excitement of tearing open that cardboard box to seeing your baby arrive — that would be wrong — but there are some similarities, the main ones being, “Wow, that came out of me?” and the realization that all the labor pains were worth it after all.

The book is about the cloning of dogs — how, and why, it came to be achieved, and the colorful characters involved: from the Arizona billionaire who funded the initial research; to the scientists who produced Snuppy, the first canine clone, in South Korea; to those who marketed the service (even before the first dog was cloned); to those who bought it, the bereaved pet owners seeking replicas of dogs dead or near death.

It was two years in the making (the book, not dog cloning) — a project I undertook right after I left the Baltimore Sun, and one that wouldn’t have been accomplished were it not for the help of a lot of people.

My first autographed copy is being sent to one of them, Rona Kim, a law student in Seoul who served as my guide and interpreter during my visit to Korea, and without whom I would have probably spent three-fourths of my time there hopelessly lost.

The official release date of “DOG, INC.” is Dec. 30, but it can be pre-ordered now from all the major retailers.

By then, Ace and I will be headed back east — first to Washington for a scheduled appearance on the Diane Rehm show Jan. 5 (me, not Ace), then to Baltimore, where we hope to host a couple of book signing parties (details to come) and find a place to call home.