Two University of Washington scientists think it might be possible to slow the aging process in canines and are launching a pilot study with 30 dogs to see if the drug rapamycin significantly extends their lifespans.
The researchers, using $200,000 in seed money from the University of Washington, plan to use pets, not laboratory animals, for the initial study, and recruit volunteer dogs — or at least dogs whose owners volunteer them — for larger scale studies in the future.
Daniel Promislow, an evolutionary geneticist, and Matthew Kaeberlein, a molecular biologist, say the study is aimed at determining whether rapamycin could lead to longer lives for dogs — as studies have shown is the case when it’s used on yeast, fruit flies, worms and mice.
“We’re not talking about doubling the healthy life spans of pets,” said Kaeberlein. “But at a minimum I would predict that you would get a 10 to 15 percent increase in average life span, and I think bigger effects are possible.”
In the pilot study, 30 large, middle-aged dogs will be involved — half receiving low doses of rapamycin, half receiving placebos.
The researchers say that subsequent studies will seek to enroll pet dogs from across the country.
Kaeberlein and Promislow hosted a meeting in Seattle last week where experts from across the country discussed the drug rapamycin and its possible effects on the health and longevity of dogs, the Seattle Times reported.
Currently used along with other medications to prevent rejection in organ-transplant patients, rapamycin has been called a promising anti-aging drug — though there have been no studies involving humans.
But almost 50 laboratory studies have shown that the compound can delay the onset of some diseases and degenerative processes and restore vigor to elderly animals, extending life spans by 9 to 40 percent.
Rapamycin functions, in part, by inactivating a protein that promotes cell growth. As a result, cells grow more slowly, which retards the spread of cancer.
Promislow, who has two elderly dogs of his own, noted that even if the drug doesn’t increase the life span of dogs, it could serve to keep them healthy longer. “We’re trying to understand why some dogs age better than others, and help all dogs age in a better way,” he said.
The drug has been shown to have serious side effects, including poor wound healing and an increased risk of diabetes, when used at the high doses required for organ transplant patients.
But the low doses used in anti-aging research with mice and other lab animals cause few side effects.
There have been no large-scale human trials. Studying how the drug affects dogs — who suffer many of the same old-age ailments as their masters — makes it possible to explore the possible benefits of rapamycin both more quickly and at a lesser cost.
If it does turn out to be a sort of fountain of youth — for dogs, humans, or both — the potential profits would be enormous.
“I think it’s worth a go, not just from what it can teach us about humans, but for the sake of the animals themselves,” said University of Alabama Biology Department Chairman Steven Austad, an expert in aging research who is not involved in the project. “It may not work in dogs, but if it did, boy, it’s going to be huge.”
According to the Seattle Times article, drug companies aren’t very interested in rapamycin because it’s no longer under patent.
But the researchers are hoping dog lovers, dog-food companies and some foundations might be willing to contribute to further research.
They’ve set up a website, dogagingproject.com,where people can donate and sign their dogs up to take part in the research.
“Given how I feel about my pets, I see this as a unique project where there’s a real potential for citizen science,” Kaeberlein said. “I think it would be great if pet owners who are really interested in improving the health of their animals would help fund this work.”
(Photos: UW scientists Matt Kaeberlein, with his dog Dobby, and Dan Promislow, with his dog Frisbee; by Steve Ringman / The Seattle Times)
Posted by John Woestendiek November 4th, 2014 under Muttsblog.
Tags: animals, anti aging, anti aging drug, biology, cancer, cells, citizen science, compound, Daniel Promislow, death, dog, dogs, drug, drugs, extending, fountain of youth, funding, geneticist, health, ifespan, laboratory, life, lifespans, lives, longer, Matthew Kaeberlein, molecular, pets, rapamycin, research, sickness, study, university of washington
Based on tests with dozens of dogs — some from homes, some from shelters — researchers found that, when it comes to interacting with humans, dogs seems to prefer physical contact to anything you might have to say, praise included.
One possible exception — verbal pronouncements that dinner, or treats, are about to be served.
Two scientists from the University of Florida, who in a previous study determined dogs prefer eating food to being petted, have published the results of another research project, showing dogs prefer physical contact over verbal praise.
Neither conclusion seems that surprising to me, but one has to bear in mind that scientists prefer having their work published to having their bellies rubbed, dinner at a five-star restaurant or even verbal praise: “Good scientist. Yes! Yes! You’re a very good scientist.”
“I spend half my day talking to my dog,” study co-author Dr. Clive Wynne, who is now professor and director of the Canine Science Collaboratory at Arizona State University, told The Huffington Post. “She always looks like it’s valuable to her. It’s quite a shock to discover that what we say to dogs doesn’t seem to be rewarding to them after all.”
For one part of the study researchers observed 42 dogs as they interacted one at a time with two people in a room. One person petted the dog, while the other praised the dog verbally. The researchers measured how much time the dog chose to spend interacting with each person.
Next, 72 dogs were, one at a time, placed in a room with just one person and their behavior was observed as the person spent time petting or praising the dog, or not interacting at all.
Dogs showed the most interest in people who were petting them, while they seemed to show no more interest in spoken praise than in having no interaction with the human at all, according to the study, published in the journal Behavioural Processes.
“I was surprised that when only one alternative was available, dogs still did not engage with the human for vocal praise,” said study co-author Dr. Erica Feuerbacher, now assistant professor of anthrozoology at Carroll College in Helena, Montana. She conducted the research while earning her doctorate degree at the University of Florida.
The scientists say dogs never seem to tire of getting petted, and they note that previous studies have shown a dog being stroked, like the human who is stroking him, reaps some health benefits, including a lowering of heart rate and blood pressure.
We won’t go so far as to suggest dogs realize that petting is a more honest form of interaction; that words can be less sincere, or even deceptive; or that words can even be annoying — like when they go on too long, are ridiculously repetitious, or they’re uttered in that high-pitched baby talk tone some of us use when talking to our pets.
But we won’t rule it out, either.
For his part, researcher Wynne says that, even if his own dog doesn’t fully appreciate all he verbally passes on to her, he’ll probably keep talking to her anyway. ”I just recognize better that I’m doing it more for my benefit than for hers,” he said.
(Photo: Ace seeking some physical contact in Kanab, Utah / by John Woestendiek)
Posted by John Woestendiek September 10th, 2014 under Muttsblog.
Tags: animals, attention, benefits, blood pressure, cognition, contact, dogs, health, heart rate, humans, interaction, pets, petting, physical, praise, psychology, science, shut up and pet me, study, talk, talking, touch, verbal, vocal, words
Lately, it seems, hardly a month goes by without either some viral video or paper-writing scientist suggesting that — contrary to what scientists and the media think we think — dogs feel emotions much like our own, or at least a doggy version of them.
If it’s not a video, like the one above – which is being described in the news media as a dog not just feeling remorse, but atoning for his misdeed — it’s a new scientific paper proclaiming, yes, dogs do feel … you name it … joy, fear, anger, guilt, pride, compassion, love, shame.
(If you didn’t already think dogs feel joy, you may not be the world’s most perceptive person.)
(Some, apparently, get so overwhelmed by it that they pass out.)
This month’s emotion? Jealousy.
Dr. Christine Harris, a psychologist at the University of California, San Diego — after a study involving dogs, their owners, stuffed animals, jack-o’-lantern and children’s books – concluded that dogs showed a “primordial” form of jealousy, meaning, I guess, not as evolved, twisted, complex, nasty and, sometimes, fatal as the human form.
According to an article in the New York Times, the dog version of jealousy is “not as complex as the human emotion, but similar in that there is a social triangle and the dog is trying to make sure it, not the rival, receives the attention.”
In the study, as it’s described in a a PLoS One paper co-written by Harris, researchers compared the reactions of dogs when their owners petted and talked to a jack-o’-lantern, read a children’s book aloud, and petted and talked to a stuffed toy dog that barked and whined.
The dogs paid little attention to the jack-o’-lantern or the book. But when dog owners petted and talked to the stuffed dog, their dogs reacted, coming over, pushing their noses into the owner or stuffed dog, sometimes barking, and sniffing the rear end of the stuffed dog.
I’m not sure that’s proof of jealousy — it could just be proof that dogs are smart enough to investigate when humans are trying to dupe them. On top of that, most dogs have experience playing with stuffed toys, as opposed to plastic pumpkins and children’s books. So it’s not too astonishing they would have a more excited reaction to them.
In that way, the findings of this study aren’t really too surprising, or revealing, but they are indicative, I think, of a trend — in the scientific community, in the news media, and among normal members of society — of seeing dogs more and more as humans.
The “dogs feel jealousy” study, for example — flimsy as its findings sound — was picked up by most major news organizations.
“Study: Jealousy Is So Universal Even Dogs Feel It,” reported the New York Times.
“Study: Dogs Can Feel Jealous, Too,” said a CNN headline.
At least NPR phrased their headline as a question: “Does Your Dog Feel Jealous, Or Is That A Purely Human Flaw?”
These days, the news media doesn’t need a legitimate study to draw sweeping conclusions; a viral video will do.
The headlines all presume to know what the beagle is feeling, and some go so far as to explain the goal of his behavior as well: “I’m Sorry! Charlie the guilty dog showers crying baby with gifts to apologize for stealing her toy,” reads the headline in The Daily Mail.
My problem is not with attributing emotions to dogs. I believe they have most of the ones we do, or at least most of the desirable ones. I believe they have other magical gifts and skills we haven’t even begun to figure out. I believe studying what’s going on in their heads is a good thing — at least when it’s done by dog experts. I can even handle a little anthropomorphization; given we’re humans we tend to interpret things in human terms.
What bothers me, for starters, is presenting such findings as new, when dog owners have known most of them all along. Sometimes, it’s as if scientists and the news media are saying, oh wait, we’ve discovered dogs are not unfeeling blobs of fur, after all. Well, duh.
The problem I have is not so much ascribing emotions to dogs as it is the vanity of assuming emotions are something only humans feel.
And feel free as well, video posters, to share your dog’s interesting and seemingly human-like behavior, and to offer any theories you might have.
But let’s not leap to wild conclusions, based on how things look through our human eyes. Let’s not forget that dogs have had emotions all along. Let’s not assume they are “catching up” with us in terms of their emotions and behaviors. Maybe they’ve been ahead of us all along.
And let’s not be so surprised — given the centuries man has been choreographing their evolution, and the half century or so they’ve been mostly living inside with us — that they’re picking up some of our habits, good and bad.
While we’re at it, let’s let dogs remain, at least in part, dogs.
Let’s keep in mind, during all this, what we can learn from them. Are dogs lagging behind us, in terms of developing a sense of jealousy, or are they exhibiting a purer form of what we homo sapiens have taken to ridiculous extremes?
And let’s at least keep our minds open to the possibility that, when it comes to what dog and man can learn from each other, we may not always be the teachers, or the role models, in that equation.
(Photos: Ace in Monterey, California, at home on the couch, and with a panhandler in Portland, Maine; by John Woestendiek / ohmidog!)
Posted by John Woestendiek July 30th, 2014 under Muttsblog, videos.
Tags: animals, anthropomorphization, cognition, dog, dogs, emotions, feelings, guilt, internet, jealousy, media, news, pets, pop culture, remorse, science, society, studies, study, trend, videos, viral, what dogs feel
Throw a dog who has never gone swimming into a pool and, pretty much instantly, he’ll start moving his four legs in a series of motions we’ve come to call the dog paddle.
Throw a human who has never gone swimming into a pool and — though the possibilities are much higher for helpless flailing about, cussing, drowning, or becoming traumatized for life — he may eventually come to his senses enough to try and work his way back to the side of the pool. He’ll do so not using a butterfly stroke, breast stroke or Australian crawl, but by doing what dogs do.
The dog paddle: It’s seemingly instinctual. It’s primitive. And though we humans mostly outgrow it, it remains sort of the default mode of propelling ourselves through water.
Just how primitive it may be is under investigation by Dr. Frank Fish, a professor of biology at West Chester University who — maybe because of his name, maybe not — has spent most of his career studying how marine mammals swim.
Most recently, he has been studying the swimming motions of dogs, and he has concluded that they are very similar to the motions dogs use in trotting. That explains the ease with which most dogs can make the transition from land to water — requiring no lessons, and (generally) little coaxing: They basically propel themselves the same way in water as they do on land.
That their stride and strokes are nearly identical is interesting in itself, but Fish thinks it could also help explain how whales and dolphins ended up in the ocean.
Fish subscribes to the theory that marine mammals were intitially four-legged land dwellers who ventured into the water one day (likely dog paddling at first), decided they liked it better there, then evolved into such super swimmers that they no longer needed legs, or, for that matter, land.
He borrowed a swimming pool used to rehabilitate horses at the University of Pennsylvania.
Analyzing the video, Fish and fellow researchers saw that dogs swim much like they run — with diagonal pairs of legs churning in unison, according to Science Daily. Fish presented his findings at the 2014 Society for Integrative and Comparative Biology (SICB) meeting in Austin.
While there’s plenty of dog research we’d categorize as a silly waste of time, we find all this pretty intriguing.
First, it reminds us that practice makes perfect — to think that long, long ago there might have been a couple of four-legged dolphins who didn’t know how to swim, hesitating at the edge of the water: “I dunno, it looks dangerous … should we go in?”
Second, in an era when we’re increasingly relying on computers to do our thinking for us, it serves as a warning that those muscles we don’t use can disappear. It raises a host of interesting questions about our future, and our past.
Why is it we humans tend to dog paddle in our first encounters with water? Is that some sort of instinctual nod to a past when we got about on four legs, instead of two?
If cavemen had spent more time at the swimming hole, might we homo sapiens have evolved into something more amphibious?
Given that, might mermaids really exist?
It’s kind of inspiring to think there might have been a day when dolphins, the planet’s most graceful swimmers, were total klutzes in the water — that they started off splashing about with some awkward looking dog paddling and progressed to the point where they could actually leap out of the water.
It reminds us that, maybe, anything is possible with enough hard work — even when it comes to behaviors we might think are genetic and therefore unchangeable. Do we sometimes wear our genes too tightly, and allow them to restrict us from leaping into new things, and getting over old ones?
We wish Fish luck in unraveling how four-legged terrestrial forms evolved into no-legged, finned ones. And as long as the dogs involved in his research are having a good time – given Fish is letting his own dog be used in the study, we assume they are – we have no problem with them helping the professor prove his point.
In other words: Go Fish!
(Top Photo, Society for Integrative and Comparative Biology; bottom photo, from the book Underwater Dogs)
Posted by John Woestendiek January 16th, 2014 under Muttsblog.
Tags: animals, biology, dog paddle, dogs, dolphins, evolution, frank fish, genes, genetics, instinct, land, legs, mammals, marine, motions, movement, nature, research, science, study, swim, swimmers, swimming, water, west chester university, whales
With all the research into how the medical issues of dogs often run parallel to our own, it’s no surprise that eight obsessive-compulsive Doberman pinschers are adding to our body of knowledge about that disorder.
A new study made use of MRI brain scans and found dogs and people with obsessive compulsive disorder (OCD) have similar brain abnormalities and share certain brain characteristics.
Three years ago, researchers found the shared gene believed responsible for flank-sucking, blanket-sucking and other compulsive behavior in Dobermans.
The new study shows what’s going on in their brains is similar — at least as an MRI sees it — to what’s going on in our’s.
“We have a lot of commonality with our best friend the dog,” said study leader Niwako Ogata, an assistant professor of animal behavior at Purdue University College of Veterinary Medicine in Indiana.
Just as elderly dogs with the canine equivalent of Alzheimer’s are being used as models to understand the degenerative disease in people, studying dogs is providing some clues into OCD, an anxiety disorder afflicting anywhere from 2 to 8 percent of Americans.
For the study, Ogata and colleagues recruited eight Doberman pinschers with CCD (canine compulsive disorder) and a control group of eight Dobermans without CCD, according to National Geographic. The team obtained MRI scans for each group and discovered that the CCD dogs had higher total brain and gray matter volumes and lower gray matter densities in certain parts of the brain. That’s similar to the structures of people brains’ with OCD.
It’s not known why both species’ brains show these features, Ogata said, but her team plans to repeat the experiment with more dogs and more breeds.
The team chose Dobermans because of the prevalence of CCD in the breed. About 28 percent of Dobermans in the U.S. are afflicted.
People with OCD often perform the same rituals over and over again, like washing and rewashing their hands and locking and relocking doors. In dogs, common compulsive behaviors include paw-licking and tail-chasing.
Ogata, whose study was published online in April in the journal Progress in Neuro-Psychopharmacology & Biological Psychiatry, said the study provides a better idea of “”how brains develop, and when and how genes interact with [their] environment to cause some behavior problems for both humans and dogs.”
Posted by John Woestendiek June 14th, 2013 under Muttsblog.
Tags: animals, behavior, blanket, brain, ccd, compulsive, disorder, doberman, dog, dogs, flank, gene, genetics, health, humans, licking, medicine, mri, Niwako Ogata, obsessive, ocd, pets, pinschers, purdue, research, science, species spanning, study, tail chasing, veterinary, zoobiquity
A new study suggests the earliest domestic dogs weren’t just kept for hunting and protection, but for loving — a premise supported by evidence that some prehistoric pet owners actually outfitted their dogs in bling, if not before death, at least after it.
An analysis of ancient dog burials, published in PLoS ONE, found that deceased dogs were often laid to rest not just with respect, but with toys and ornaments, Jennifer Viegas reports on Discovery.com.
The findings show that, at least as recently as 10,000 years ago, dogs were valued for more than their ability to stand sentry and track game.
The researchers also say the earliest dog lovers were fish-eaters, and held spiritual beliefs. Subsisting on diets rich in seafood, they apparently didn’t rely on dogs to help them find dinner, or as dinner.
“Dog burials appear to be more common in areas where diets were rich in aquatic foods because these same areas also appear to have had the densest human populations and the most cemeteries,” Robert Losey, lead author of the study told Discovery News.
“If the practice of burying dogs was solely related to their importance in procuring terrestrial game, we would expect to see them in the Early Holocene (around 9,000 years ago), when human subsistence practices were focused on these animals,” Losey, a University of Alberta anthropologist, added. “Further, we would expect to see them in later periods in areas where fish were never really major components of the diet and deer were the primary focus, but they are rare or absent in these regions.”
For the study, Losey’s team researched dog burials worldwide, but focused particularly on ones located in Eastern Siberia. The earliest known domesticated dog was found there, dating to 33,000 years ago. Dog burials in the region are more recent, going back about 10,000 years.
They found that dogs were sometimes buried with meaningful items, sometimes even their human, showing that man’s bond with dog — while it may be ever-strengthening — goes way, way back.
According to the Discovery report:
“…One dog, for example, was laid to rest “much like it is sleeping.” A man was buried with two dogs, one carefully placed to the left of his body, and the other to the right. A dog was buried with a round pebble, possibly a toy or meaningful symbol, placed in its mouth. Still other dogs were buried with ornaments and implements, such as spoons and stone knives.
“One of the most interesting burials contains a dog wearing a necklace made out of four red deer tooth pendants. Such necklaces appear to have been a fashion and/or symbolic trend at the time, since people wore them too.”
The researchers found that most of the dog burials in the area occurred during the Early Neolithic era, about 8,000 years ago.
(Photo by Robert Losey, via Discovery.com)
Posted by John Woestendiek May 22nd, 2013 under Muttsblog.
Tags: animals, bling, burial, death, dog, dogs, domesticated, earliest, fish, grieving, man, mourning, pets, prehistoric, research, robert losey, seafood, siberia, spirituality, study, univerisity of alberta, wolf
In a collaboration between Penn and the Monell Chemical Sciences Centers, Ohlin and McBain (above) and Thunder (left) will use their noses to detect the disease in humans.
Ovarian cancer kills more than 14,000 women every year and is the fifth leading cause of cancer-related deaths in women in the nation.
The collaboration, the Philadelphia Inquirer reports, takes aim at the silent killer with a combination of chemistry, nanotechnology — and dogs.
Canines have been detecting lung and breast cancer for years. With an $80,000 grant from the Kaleidoscope of Hope Foundation, the new project will assess their effectiveness in sniffing out ovarian cancer, and continue an investigation that has been underway in Sweden.
The Swedish professor behind that project, who was using his own dogs for the study, is retiring. But he’s lending his expertise to those involved in the Penn project.
“He’s been advising us along the way to we don’t repeat the same mistakes he made along the way,” said Dr. Cynthia Otto, director of the Working Dog Center and Associate Professor of Critical Care at Penn Vet.
While the disease is often difficult to diagnose, ovarian cancer’s victims have a survival rate of 90 percent. No effective screening protocol yet exists to detect cases in the early stages.
In the new program, scientists from Penn Medicine’s Division of Gynecologic Oncology will take tissue and blood samples from both healthy and ovarian cancer patients. The samples will be analyzed by chemists, scientists, computers and the puppies at the Working Dog Center, who will be exposed to healthy samples and cancer samples in vented containers they can’t access, but can smell.
The dogs began their training at 8-weeks of age.
“They’re all fabulous and they are very strong in olfaction,” Otto said.
(Photos: Philadelphia Inqurer)
Posted by John Woestendiek May 9th, 2013 under Muttsblog.
Tags: animals, cancer, cancer sniffing, chocolate labs, collaboration, detect, detecting, detection, dog, dogs, Kaleidoscope of Hope Foundation, mcbain, medicine, Monell Chemical Sciences Centers, ohlin, ovarian, ovarian cancer, penn, pets, project, research, science, sniff, sniffing, springer spaniel, study, thunder, university of pennsylvania, working dog center