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Tag: university of washington

A drug to make your dog live longer?

antiaging

Two University of Washington scientists think it might be possible to slow the aging process in canines and are launching a pilot study with 30 dogs to see if the drug rapamycin significantly extends their lifespans.

The researchers, using $200,000 in seed money from the University of Washington, plan to use pets, not laboratory animals, for the initial study, and recruit volunteer dogs — or at least dogs whose owners volunteer them — for larger scale studies in the future.

Daniel Promislow, an evolutionary geneticist, and Matthew Kaeberlein, a molecular biologist, say the study is aimed at determining whether rapamycin could lead to longer lives for dogs — as studies have shown is the case when it’s used on yeast, fruit flies, worms and mice.

“We’re not talking about doubling the healthy life spans of pets,” said Kaeberlein. “But at a minimum I would predict that you would get a 10 to 15 percent increase in average life span, and I think bigger effects are possible.”

In the pilot study, 30 large, middle-aged dogs will be involved — half receiving low doses of rapamycin, half receiving placebos.

The researchers say that subsequent studies will seek to enroll pet dogs from across the country.

Kaeberlein and Promislow hosted a meeting in Seattle last week where experts from across the country discussed the drug rapamycin and its possible effects on the health and longevity of dogs, the Seattle Times reported.

Currently used along with other medications to prevent rejection in organ-transplant patients, rapamycin has been called a promising anti-aging drug — though there have been no studies involving humans.

But almost 50 laboratory studies have shown that the compound can delay the onset of some diseases and degenerative processes and restore vigor to elderly animals, extending life spans by 9 to 40 percent.

Rapamycin functions, in part, by inactivating a protein that promotes cell growth. As a result, cells grow more slowly, which retards the spread of cancer.

Promislow, who has two elderly dogs of his own, noted that even if the drug doesn’t increase the life span of dogs, it could serve to keep them healthy longer. “We’re trying to understand why some dogs age better than others, and help all dogs age in a better way,” he said.

The drug has been shown to have serious side effects, including poor wound healing and an increased risk of diabetes, when used at the high doses required for organ transplant patients.

But the low doses used in anti-aging research with mice and other lab animals cause few side effects.

There have been no large-scale human trials. Studying how the drug affects dogs — who suffer many of the same old-age ailments as their masters — makes it possible to explore the possible benefits of rapamycin both more quickly and at a lesser cost.

If it does turn out to be a sort of  fountain of youth — for dogs, humans, or both — the potential profits would be enormous.

“I think it’s worth a go, not just from what it can teach us about humans, but for the sake of the animals themselves,” said University of Alabama Biology Department Chairman Steven Austad, an expert in aging research who is not involved in the project. “It may not work in dogs, but if it did, boy, it’s going to be huge.”

According to the Seattle Times article, drug companies aren’t very interested in rapamycin because it’s no longer under patent.

But the researchers are hoping dog lovers, dog-food companies and some foundations might be willing to contribute to further research.

They’ve set up a website, dogagingproject.com,where people can donate and sign their dogs up to take part in the research.

“Given how I feel about my pets, I see this as a unique project where there’s a real potential for citizen science,” Kaeberlein said. “I think it would be great if pet owners who are really interested in improving the health of their animals would help fund this work.”

(Photos: UW scientists Matt Kaeberlein, with his dog Dobby, and Dan Promislow, with his dog Frisbee; by Steve Ringman / The Seattle Times)

How the sharpei got its wrinkles

sharpei2

 
How did the sharpei get its wrinkles?

Scientists who have analyzed the genetics of 10 dog breeds say they’ve found the answer — and a path to many more.

While five genes have already been pinpointed as being responsible for dogs’ coats, leg size and more, the new research identifies 155 distinct locations in the animals’ genetic code that could play a role in giving breeds their distinctive appearances.

In the sharpei, the team found differences in a gene known as HAS2 which makes an enzyme known to be important in the production of skin.

“There was probably a mutation that arose in that gene that led to a really wrinkly puppy and a breeder said, ‘hey, that looks interesting, I’m going to try to selectively breed this trait and make more of these dogs’,” explained Joshua Akey from the Department of Genome Sciences at the University of Washington, told the BBC.

Akey and colleagues studied 32 wrinkled and 18 smooth-coated sharpeis and compared a specific stretch of their DNA with that of other breeds.

The team found four small, but significant, differences in the genetics of the two skin types of the sharpei versus the other breeds. These single nucleotide polymorphisms (SNPs), as they are called, were located in the HAS2 gene.

The research has also identified other locations in the dog genome that can now be investigated further to understand better why pedigree animals look the way they do.

Akey and his colleagues reported their findings in the Proceedings of the National Academy of Sciences.

Home of Huskies bans dogs from buildings

The University of Washington — home, ironically enough, of the Huskies — has banned dogs from campus buildings.

The UW Board of Regents decided in a meeting last month that non-service animals will no longer be permitted inside buildings, according to The Daily, the student newspaper.

The changes also prohibit leaving animals unattended or tethered to campus property and allows them to be seized and impounded.

UW Police Department Assistant Chief Ray Wittmier said the new policy followed a dog bite incident in Parrington Hall.

Wittmier said the department would respond to complaints and ask pet owners to take their animals out of a building. Owners would be cited or banned from campus if they refuse.

“[Violators] will always get a warning first,” Wittmier said. “If somebody doesn’t have ties to campus, they could be banned. Someone on campus will be handled as an employment-type issue. Employment could be terminated. Other actions could affect students and their student status.”

No word on whether the changes apply to Dubs, the dog that serves as school mascot. Judging from his blog, he seems to be allowed indoors, or at least inside the football stadium and basketball arena.